The Clinical Study on Relationship between Plasma Homocysteine Levels and Recurrent Cerebral Infarction

Objective:Based on the early cerebral infarction and relapse in patients with plasma homocysteine (Hcy) level to discuss the relationship between the recurrent cerebral infarction and plasma homocysteine.For the prevention of ischemic cerebrovascular disease and open new avenues for treatment.Metuods:This study selected in June 2010-2011 period in January in the Second Affiliated Hospital of Dalian Medical University,Department of Neurology,100 patients hospitalized with acute cerebral infarction patients as research subjects,and the other select the same period,50 patients with non-hospitalized patients with acute cerebral infarction (such as Parkinson’s disease,peripheral neuropathy,motor neuron disease,headache,benign positional vertigo,etc.) as a control group.The study (100 patients) were divided into different clinical subgroups - all types of acute cerebral infarction (atherosclerosis of cerebral thrombosis,cardiogenic cerebral embolism group, lacunar infarction group),the initial issuance of group Relapse group,measured by enzymatic cycling 100 patients with acute cerebral infarction and 50 cases of non-plasma Hcy levels in patients with acute cerebral infarction were compared among groups with high plasma Hcy levels and Hcy ratio.At the same time after admission electrocardiogram and echocardiography routinely check blood pressure,blood glucose, blood lipids (including total cholesterol TC,triglyceride TG,low density lipoprotein cholesterol,LDL-C,high density lipoprotein cholesterol HDL-C), cerebral infarction A multivariate analysis of recurrence.Results:1.Plasma Hcy levels in patients with recurrent cerebral infarction onset than patients (P<0.01),and the relapse rate of homocysteine group (54.45%) than onset group (32.83%),the difference was statistically significant (P<0.05).2.Various types of plasma Hcy in patients with acute cerebral infarction was higher than non-acute cerebral infarction,the difference was statistically significant (P<0.05); various types of plasma Hcy levels between patients with cerebral infarction was no significant difference (P>0.05).3.1 year and 1 year after the plasma Hcy levels in patients with recurrent cerebral infarction was no significant difference (P>0.05).4.Between various types of plasma Hcy in patients with recurrent cerebral infarction was no significant difference (P>0.05); recurrent thrombosis in patients with cerebral infarction rate slightly higher than the other types of high Hcy infarction (P>0.05).5.Multivariate analysis showed that cerebral infarction recurrence and high Hcy levels, diabetes (P<0.01, P<0.05).Conclusions:1. Hcy plasma of patients with recurrent cerebral infarction was higher than the initial issuance of patients,suggesting the recurrence of cerebral infarction increased with plasma Hcy levels is closely related to high plasma Hcy levels are independent risk factors for recurrence of cerebral infarction.2. Different types of plasma Hcy levels of patients with cerebral infarction was no significant difference,suggesting that it may have a common basis of disease - atherosclerosis.3.High plasma Hcy level has nothing to do with the time of recurrence of cerebral infarction.