Dissertation > Medicine, health > Neurology and psychiatry > Psychiatry > Cerebral organic mental disorder

A Study of Related Factors to Post-stroke Depression of Patients with First-onset of Cerebral Apoplexy

Author LiZuoZuo
Tutor WangJianFeng
School Dalian Medical University
Course Neurology
Keywords Post-stroke depression lesion location OCSP classification neurological deficit
CLC R749.1
Type Master's thesis
Year 2011
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Objective:1) To study the relationship between post-stroke depression (PSD) and stroke lesion locations;2) To discuss the relationship of PSD and different subtypes of ischaemic stroke according to ischemic stroke OCSP classification; 3) To observe the effect of PSD to the recovery of neurological deficits .Methods:1.To observe the prevalence of PSD and the recovery of neurological deficits among 114 patients with first-attack of cerebral apoplexy for one year after acute stroke. According to HAMD scale and whether depression accurs the patients were divided into two groups: depression group and non-depression group.2.To study the prevalence of PSD in three periods(acute period、resumptive period and Sequela period)after acute stroke between different stroke lesion locations .3.To compare the prevalence of PSD between four subtypes of ischemic stroke according to OCSP classification. 4.According to NIHSS scale, to evaluate the recovery of neurological deficits in acute period and resumptive period. 5.The datas were analysed by Statistical software SPSS11.5.Results:1.The prevalence rate of PSD was 33.3% in the study.There were no significant differences in age、gender、grade of education、cognitive function(MMSE scale)、Type of stroke between two groups.But better family support had lower prevalence of PSD.2.There was no relativity between lesion locations in the left or in the right hemisphere and between foreside or rearward of the left hemisphere.The lesion locations in the foreside of the left hemisphere of brain had higher prevalence of PSD in the resumptive period after acute stroke.3.There were also no significant differences in several lesion locations such as cerebral cortex and under the cortex、frontal lobe、the basal ganglia and inner capsule、brainstem、cerebellum.4.Partial anterior circulation infarcts (PACI) had higher prevalence of PSD, than posterior circulation infarcts (POCI) and lacunar infarct (LACI). 5.The recovery of neurological deficits of patients with PSD was worse than non-depress patients in resumptive period after acute stroke.Conclusion:1) The lesion location in the foreside hemisphere especially foreside of the left hemisphere of brain is relevant to the higher prevalence of PSD in the resumptive period after acute stroke.2) Anterior circulation infarcts (PACI) is a risk factor to PSD.3) The occurrence of PSD hinder the recovery of neurological deficits especially in resumptive period after stroke.

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