Dissertation
Dissertation > Medicine, health > Ophthalmology > Eye surgery and surgery

The Analysis of the Growth Factor Related with the Secondary Glaucoma in the Anterior Champer of Silicone Oil-filled Eyes

Author CaoMingZhe
Tutor ZuoYan
School Dalian Medical University
Course Ophthalmology
Keywords Silicone oil filled eyes Secondary glaucoma Vascular endothelial growth factor (VEGF) Basic fibroblast growth factor (bFGF) Aqueous humor
CLC R779.6
Type Master's thesis
Year 2011
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Objective: To determine silicone oil tamponade secondary glaucoma aqueous humor vascular endothelial growth factor and basic fibroblast growth factor levels in silicone oil tamponade secondary explore the potential role of glaucoma , as well as growth factor levels in aqueous humor the relationship between changes and IOP . Methods: double antibody sandwich enzyme-linked immunosorbent assay (ELISA) to detect the quantitative VEGF and bFGF levels in aqueous humor . Experimental groups as follows: ① 18 patients with senile cataract as normal control group 20 silicone oil tamponade secondary glaucoma ② 16 patients 16 as a patient group (SOF group ) ③ complexity eyes with retinal detachment (CRD group ) 16 Example 16 . Among the groups of age, gender difference was not statistically significant (P gt; 0.05). Results : SOF anterior chamber of patients were significantly higher than normal water VEGF control group and CRD group , bFGF was significantly lower than the control group and the CRD group , the differences were statistically significant (P lt; 0.05); SOF former patients VEGF levels in aqueous humor and the intraocular pressure and silicone oil filling time was positively correlated (r = 0.905,0.915, P lt; 0.05), bFGF content and intraocular silicone oil filling time and no significant correlation . CRD group and normal control group, the aqueous humor VEGF and bFGF were not significantly different (P gt; 0.05). Conclusion: Patients with secondary glaucoma eyes filled with silicone oil in aqueous humor were significantly increased VEGF , bFGF decreased significantly , suggesting that both the silicone oil tamponade secondary glaucoma progression has a certain effect.

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