Dissertation
Dissertation > Medicine, health > Dermatology and Venereology > Dermatology > Skin appendages and organs diseases > Hair Diseases

The Expression of CD4+CD25+ Regulatory T Cell、TGF-β1 on Peripheral Blood from Patients with Alopecia Areata

Author SuiJiaJia
Tutor ChenXiaoHong
School Zunyi Medical College,
Course Dermatology and Venereology
Keywords Alopecia areata CD4 ~ CD25 ~ regulatory T cells Transforming growth factor -β1
CLC R758.71
Type Master's thesis
Year 2011
Downloads 27
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Objective: To detect alopecia (alopecia areata, AA) in patients with peripheral blood CD4 CD25 Treg cells, transforming growth factor -β1 (transforming growth factor-β1, TGF-β1 expression levels in alopecia areata explore their role in the pathogenesis . methods: 50 cases detected by flow cytometry in untreated patients with alopecia areata in peripheral blood CD4 CD25 Treg cell levels , ELISA assay of serum TGF-β1 levels, and correlation analysis , to 30 healthy volunteers served as normal controls. results : Peripheral blood CD4 CD25 Treg cells in the normal ratio of T lymphocytes in the control group (12.21 ± 2.80)%, alopecia areata patient group was (10.05 ± 2.10)%, alopecia areata patients and normal control group, the difference was statistically significant (t = 3.93, P lt; 0.01); severe alopecia areata patients (8.10 ± 1.35)%, localized alopecia areata was (10.89 ± 1.78)%, the difference was statistically significant (t = 5.40, P lt; 0.01 ) serum TGF-β1 content of normal control group (32.14 ± 17.92) ng / ml, alopecia areata patients (18.09 ± 17.02) ng / ml, alopecia areata patients and normal control group, the difference was statistically significant (t = 3.51, P lt; 0.01); severe alopecia areata patients (6.51 ± 2.02) ng / ml, localized alopecia areata patients (23.05 ± 18.20) ng / ml, the difference was statistically significant (t = 5.30, P lt; 0.01). alopecia areata patients with CD4 CD25 Treg cell expression and SALT score was significantly negatively correlated (r = -0.566, P lt; 0.01); serum TGF-β1 content SALT score was significantly negatively correlated (r = -0.471, P lt ; 0.01 ) , peripheral blood CD4 CD25 Treg cell counts and serum TGF-β1 expression levels were significantly correlated (r = 0.584, P lt; 0.01). conclusions: patients with alopecia areata in peripheral blood CD4 CD25 Treg cells and serum TGF- β1 was some correlation , and both with alopecia areata disease severity . CD4 CD25 Treg cells and reduce the number decreased expression of TGF-β1 may be associated with alopecia areata cellular immune disorders.

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