Dissertation
Dissertation > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Bowel disease

Survey of Sleep Habits in Irritable Bowel Syndrome Patient

Author WuJunPing
Tutor SongZhenYa
School Zhejiang University
Course Internal Medicine
Keywords Irritable bowel syndrome (IBS) Self-Rating Anxiety Scale ( SAS ) Self-Rating Depression Scale (SDS) Pittsburgh Sleep Quality Index Index (PSQI)
CLC R574
Type Master's thesis
Year 2008
Downloads 118
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Preface: Irritable Bowel Syndrome (irrtable bowel syndrome, IBS) is a group of intestinal dysfunction syndrome, without any organic or biochemical indicators of abnormal, its main symptom is abdominal discomfort and (or) pain and chronic intermittent change in bowel habits and stool consistency, sometimes accompanied by a series of symptoms of the other systems of the body. Although IBS is not a fatal disease, but the crowd high prevalence of symptoms of patients suffering from this disease a lot longer duration, although a variety of advanced means of checking its structure, metabolism, or is quality, but often can not be found more difficult sexual abnormalities, diagnosis, treatment, patients often multi-run seek medical attention and wasted high medical resources, significantly affect the social production, affecting the quality of life of patients. IBS pathogenesis is not yet clear, may be related to a variety of factors, including psychological factors, including anxiety, depression, fear, sleep disorders, and psychological coping disorders play a role. Psychological factors, especially anxiety and depression can affect the patient's quality of sleep, for IBS patients, the relationship between sleep quality and psychological factors: quality of sleep and psychological factors related to, or independent of psychological factors and sleep disorders and digestive tract related to the severity of symptoms. Little these studies at home and abroad. Objective: This study of IBS patients gastrointestinal symptoms, sleep quality, anxiety and depression, self-assessment, to understand the situation on the basis of the patient's sleep quality and anxiety and depression, further analysis of the anxiety associated with depression and anxiety and depression in patients with IBS sleep quality differences in severity of gastrointestinal symptoms and sleep-related sleep disorders to explore the role and status in the pathogenesis of IBS patients, and provide the basis for clinical treatment. Subjects and Methods: to meet the the the IBS Rome Ⅲ diagnostic criteria of IBS patients as research subjects, the same period Enterprises healthy volunteers as a control group. Survey method, investigation-related symptoms in patients with IBS (IBS-related symptoms questionnaire), sleep quality (Pittsburgh Sleep Quality Index Scale PSQI), anxiety Points (anxiety and depression integral self-rating scale SAS) (Self-Rating Depression Scale SDS ). Comparative analysis of the two sets of sleep and the anxiety and depression; According to SAS, SDS integral grouped IBS group and compared with each other as well as compared with the control group, analysis of each group of sleep; IBS-related factors by multivariate regression analysis. Results: 1, General Information: IBS patient group, a total of 145 cases, 63 males and 82 females, average age 43.29 ± 12.35 (19 ~ 74) years of age, gastrointestinal symptoms average 2.32 ± 0.456; the control group, 59 cases 28 males, 31 females, mean age 40.01 ± 14.31 (19 ~ 72) years of age. IBS patients with diarrhea-predominant IBS patients 68.28% (99/145 patients), constipation-predominant IBS patients was 14.48% (21/145 patients), mixed IBS patients 17.24% (25/145 patients). 2, IBS patients with anxiety and depression rating: IBS group SAS roughly divided 29.43 ± 15.24, SAS ≥ 40 points positive rate of 12.41% (18/145 patients), year-on-year, the control group SAS coarse sub-26.10 ± 11.55 SAS ≥ 40 points positive rate of 3.39% (2/59) the difference was statistically significant (p <0.05). SDS rough segmentation of the IBS group 31.29 ± 13.32, a year-on-year control group SDS roughly divided 26.5l ± 13.91 difference was significant (p <0.05), the IBS group SDS ≥ 40 points positive rate of 3.39% (10/145 patients), a year-on-year control group SDS ≥ 40 points positive rate of 6.90% (4/59 cases), the difference was not statistically significant (P> 0.05). That IBS patients with mood disorders, and anxiety is more prominent. IBS patients with sleep: IBS Group three factors in the quality of sleep, sleep disorders, and daytime dysfunction, as well as the PSQI total score of the control group, the difference was significant (p <0.05), while the sleep time, sleep time, sleep efficiency and hypnotic drugs four factors with the control group, the difference was not significant (p> 0.05). That IBS patients than in the control group there are some factors sleep disorders. 4, anxiety and depression IBS patients with sleep impact analysis: 125 cases of anxiety and depression in patients with IBS compared with control group in sleep quality, sleep disturbance, daytime dysfunction factor 3 and PSQI total score difference (p <0.05), while the sleep time, sleep time, sleep efficiency, sleep medication factor 4 with the control group showed no differences (p> 0.05). 20 patients with anxiety and depression in patients with IBS compared with control group, sleep quality, sleep time, sleep efficiency, sleep disorders, sleep duration, daytime dysfunction factor 6 and PSQI total score differences (p <0.05). Only hypnotic drugs no difference (p> 0.05). IBS patients with anxiety depression anxiety and depression in patients with IBS sleep quality, sleep time, sleep time, sleep efficiency, sleep disturbances, and daytime dysfunction, hypnotic drugs all seven factors and PSQI total score, were different (p <0.05). Severity of IBS symptoms in patients with sleep quality, anxiety and depression in comparison: the group of IBS patients, patients with mild 61.38% (89/145 patients) in patients with moderate 22.76% (33/145 patients), 15.86% of the patients with severe IBS (23/145 cases), the patients in each group PSQI score ≥ 7 points, respectively, accounting for 38.20% (34/89), 42.36% (14/33 cases), 43.47% (10/23 cases). The positive rate of patients in each group SAS roughly divided ≥ 40 points, respectively, accounted for 5.62% (5/89), 18.18% (6/33 cases), 30.43% (7/23). Patients in each group SDS roughly divided into 40 sub-positive rate of 7.86% (7/89), 6.06% (2/33 cases), 4.35% (1/23 patients). Mild, moderate, severe IBS patients PSQI positive rate and the SDS positive rate difference was not significant (p> 0.05), SAS positive rate difference was statistically significant (p <0.05) in patients with gastrointestinal symptoms scoring SAS crude was positively correlated (r = 0.149, P = 0.025). 6 different Labor nature, a different gender IBS patients sleep comparison: comparison of the manual labor IBS patients with mental IBS patients, sleep quality, sleep efficiency, sleep disorders, and PSQI total score, the difference was statistically significant (p <0.05). Sleep time, sleep time, daytime dysfunction and hypnotic drugs the difference was not significant (p> 0.05). No significant differences in sleep between different gender IBS patients. IBS multi-factor correlation analysis: IBS gender, age, depression (SDS) is roughly divided, sleep disturbance (PSQI total score) regression analysis was not statistically significant (p> 0.05), and anxiety (SAS) rough segmentation, labor nature regression analysis was statistically significant (p <0.05), which, anxiety as risk factors (β = 0.064 exp (β) = 1.066), mental as protective factors (β = -1.017, exp (β) = 0.0362) . Conclusion: IBS patients sleep abnormalities, mainly in the abnormal sleep quality, sleep disturbance, daytime dysfunction factor 3 and PSQI score. IBS patients with sleep abnormalities and their severity of gastrointestinal symptoms, IBS type, gender, age, no significant correlation. 3, IBS patients with mood disorders such as anxiety and depression. 4, anxiety, depression and mood disorders will aggravate IBS patients with sleep abnormalities.

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