Dissertation
Dissertation > Medicine, health > Oral Sciences > Oral medicine > Periodontal disease

Alkaline Phosphatase Activity in Gingival Tissues of Experimental Periodontitis in Rats

Author YiXiangHao
Tutor HeJianMin
School Lanzhou University
Course Clinical Stomatology
Keywords Alkaline phosphatase Periodontitis Correlation
CLC R781.4
Type Master's thesis
Year 2009
Downloads 67
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Objective: To study alkaline phosphatase (alkaline phosphatase, ALP) in rats with experimental periodontitis gingival tissue content and distribution , and periodontitis correlation . : Successfully established model of experimental periodontitis in rats respectively modeling four weeks and were sacrificed at 8 weeks after surgery . Remove modeling at the gum tissue was determined using a microplate reader ALP content of rat gingival tissue ; tissue sections of ALP Gomori modified Gomori production and distribution of alkaline phosphatase in gingival tissue sections in the light microscope . The results : 1 . Alkaline phosphatase in the gum tissue changes in the content of ALP in modeling after 4 weeks and 8 weeks periodontitis group gum tissue was significantly higher than the normal control group ( P <0.01 ) . ALP in gingival tissue in periodontitis group , modeling group after 8 weeks were significantly higher than four weeks after surgery group (P <0.01). 2 . Alkaline phosphatase in the gingival tissue distribution of ALP in the modeling after 4 weeks and the distribution density of the gingival tissue sections of 8 weeks periodontitis group was significantly higher than the normal control group . Modeling periodontitis group 8 weeks after surgery gum tissue slice distribution density of the ALP was significantly higher than four weeks after the group . Conclusion: In this study, through the establishment of animal models of experimental periodontitis observed : periodontitis group modeling postoperative 4 weeks significant periodontal tissue destruction , the ligated teeth near and far , and the root bifurcation of the alveolar bone resorption in the gum tissue the ALP content also significantly higher than the normal control group . Modeling eight weeks after periodontal tissue damage is more significant , ligation of the teeth as well as the adjacent teeth alveolar bone absorption , showing anti- wave -shaped defect in the gum tissue ALP content was significantly higher than four weeks after . Thus , the content of the ALP in the experimental periodontitis group gum tissue was significantly higher than the normal control group , and its content was significantly higher with the progress of periodontitis , suggesting that the content of the gum tissue ALP periodontitis the progress of a positive correlation between .

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