Dissertation > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > The Chinese herbal medicine preparations of the production

Study on Fat-soluble Components from Panax Japonicus C.A.Mey

Author QianLiNa
Tutor ChenPing;ChenXin
School Wuhan Polytechnic University
Course Applied Chemistry
Keywords Panax japonicus Fat-soluble ingredients Activity evaluation
Type Master's thesis
Year 2009
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Panax japonicus Araliaceae bamboo ginseng Panax japonicus CAMey. Dried roots valuable Chinese herbal medicine, Chinese Pharmacopoeia, comprehensive utilization of development of this medicinal resources, fat-soluble constituents for the first time to carry out the system research and evaluation of pharmacological activity, the main contents are as follows: 1, the extraction of of Panax japonicus fat-soluble ingredients, separation, purification and structure identification: for the first time isolated monomer from the jaw production Panax japonicus identification and structure elucidation of compounds, manager, four compounds were respectively the Panax japonicus saponins IV a oleanolic acid-3-O-beta-D-glucopyranose aldehyde acid-28-O-beta-D-topiramate furans glucosidase] (1), Aralia saponins A [oleanolic acid-3-O-beta-D-glucopyranose (1 → 2)-beta-D-gluco-glucuronide - (1 → 4) -alpha-L-arabinofuranosyl-28-O-beta-D-pyran-glucopyranoside] (2), of Panax japonicus saponin I b [oleanolic acid-3-O-beta-D-glucopyranosyl (1 → 2)-beta-D-glucopyranosyl uronic acid - (1 → 4)-alpha-L-arabinofuranosyl - (1 → 6)-beta-D-gluco-glucopyranoside] (3), Panax japonicus saponins V [oleanolic acid-3-O-beta-D-glucopyranose (1 → 2)-beta-D-pyran-glucuronic acid-28-O-β-D-glucopyranoside (4 ) are known compounds. , Panax japonicus process optimization and quality standards: HPLC method was established for the first time in Panax japonicus Panax japonicus saponins V content determination methods and standards were used Panax japonicus saponins and ginsenoside Re bamboo section ginseng saponin V for the extraction process of evaluation on Panax japonicus is to filter out the best extraction process, isolated total saponins of Panax japonicus yield reached 24.15%, of Panax japonicus saponin the Ⅴ content of 5.97%. 3, respectively, of total saponins of Panax japonicus and four compounds were active evaluation study: the first use of computational chemistry - biofilm Chromatography technology and pharmacological models were observed and evaluated bamboo ginseng roots, ground part of the total saponins and four compounds were anticoagulant, anti-inflammatory and analgesic, anti-fatigue, anti-oxidation pharmacological activity. Experimental results show that: the Panax japonicus the total saponins have significant anti-clotting, anti-inflammatory and analgesic, anti-fatigue, anti-oxidant activity, different parts of the bamboo ginseng total saponins have similar pharmacological activity; Panax japonicus saponins IV a, Aralia saponins A, Panax japonicus saponin Ⅰ b, GP Ⅱ b / Ⅲ a receptor inhibitory activity. Pharmacological research results more consistent with its clinical efficacy.

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