To Analyse the Related Risk Factors of AMI in Aged Patients with Coronary Heart Disease.

ObjectiveTo retrospectively analyze the related risk factors of acute myocardial infarction (AMI) in aged patients with coronary heart disease would offer the theory basis of controlling risk factors effectively and reducing the mortality of AMI.MehtodsCollection of cases based on the clinical situation, divided into two parts: Part I: Statistics common risk factors for acute myocardial infarction and the clinical laboratory indicators commonly used to analyze the effects in patients with coronary heart disease the onset of acute myocardial infarction; Part II: Collection of blood samples, extract the relevant genes, statistics, analyze its effects on coronary heart disease of patients with acute myocardial infarction.1、Part I: Select 105 coronary angiography aged patients(≥60 years old) from the second Artillery General Hospital, from 2009.05 to 2010.02.The selected standards are: The AMI group (group A), 36 persons, the non-AMI group (group B), 69 Persons. The differences of age, sex composition don’t have statistically significant. Record all Patients medical history and medical examination in detail, and collect the fasting venous blood the next morning to measure the blood tests and routine biochemical etc.2、Part II: Select 162 coronary angiography aged patients(≥60 years old) from the second Artillery General Hospital, from 2009.05 to 2010.12. The selected standards are: The AMI group (group A), 54 persons, the SAP group (group B), 108 persons, and the normal of coronary angiography is group C, 34 patients. Record all patients medical history and medical examination in detail, and collect the fasting venous blood the next morning to measure the aldehyde dehydrogenase-2 gene, blood tests and routine biochemical etc.Results1、Part I: The AMI patients with glutamic-pyruvic transaminase (ALT), aspartate aminotransferase (AST), creatinine (CR) , white blood cell (WBC), the precent of neutrophilic granulocytes (NEUT%) and high sensitive C reactive protein (hs-CRP) was greatly higher than that of non-AMI Patients, however, hypertension history and triglyceride (TG) was much lowe(rP<0.05). The percentage of smoking, diabetes, family histroy, the values of total choleseterol (TC), low density lipoprotein (LDL) and blood platelet (PLT) doesn’t have statistical significance (P>0.05) in two groups (sheet 1).2、Part II:The rate of GA/AA of ALDH-2 in group A was much greatly than group B or group C, has statistical significance(P<0.05).Conclusion1、Part I: Some inflammatory cytokines such as hs-CRP could cause sever functional damages in vascular endothelium and its cells, increased blood viscosity, trigger the formation and rupture of vulnerable Plaque, increase incidence of coronary thrombosis, which is one of the most major morbidity of AMI, however, hypertention history could reduce the morbidity of AMI ; in coronary heart disease, the values of TC, LDL and PLT don’t extra effects to AMI; The TG was de-creased more Prominently in AMI group, which shows no corelation between TG and AMI;WBC, NEUT% is increased in AMI, which is a Performance of the body stress. The serum ALT, AST and CR is elevated during AMI group, which remind us Protecting the vital organs, especially kidney and liver, while the treatment of AMI.2、Part II:The GA/AA of ALDH-2 maybe one of risk factories of AMI in Beijing Han aged patients with coronary heart disease.