Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Esophageal tumors

The Different Serum Proteomics Analysis in in Patients with Esophageal Neoplasms Treated by Chemoradiation in Kazak Nationality in Xinjiang

Author ZhouFeng
Tutor ZhangLi
School Xinjiang Medical University
Course Oncology
Keywords Kazak esophageal neoplasms radiotherapy and chemotherapy serum proteomics
CLC R735.1
Type Master's thesis
Year 2011
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Objective:Xinjiang region is one of the high esophageal cancer,Esophageal cancer incidence and mortality of malignant tumor mortality in fourth place,Most patients of esophageal carcinoma(EC)have developed to advanced stages at the time of diagnosis and more than a half have either unresectable tumors or radiographically visible metastases. The 5-year survival rate was 30%-48%for all patients of EC who were after radical excision. The 5-year survival rate was less than 10% for all patients of EC. But a 5-year survival rate of 84.1% and a 10-year survival rate of 73%would be achieved if the patients were diagnosed in early stage. Therefore, looking for early diagnosis of esophageal cancer sensitive molecular biomarkers and individual treatment method at present, has become the main clinical and basic research direction. The proteins developed in recent years to two-dimensional liquid chromatographic system technology is expected to solve this difficult problem. This study aimed to through the protein two-dimensional liquid chromatographic system (Proteome LabTM PF-2D) technical analysis xinjiang kazak healthy crowd and esophageal patients before chemoradiation serum protein group characteristics, this paper discusses the changes of esophageal patients chemoradiation related protein expression spectrum influence. And further screening minority areas of esophageal cancer, preliminarily established differences protein the xinjiang minority nationality serum protein group maps of esophageal cancer in its early, try to model the esophageal cancer diagnosis function, and explore the clinical value of indiidual therapy.To discuss different serum proteome expression between Kazak esophageal neoplasms patients and normal population by the different symptoms of serum proteomics around chemoradiation in Xinjiang. Methods:We respectively collected and prepared sera of esophageal carcinoma from Kazak esophageal neoplasms patients (10cases) and normal population (10cases), and separated and processed data using 2-dimensional liquid phase chromatography system specific for protein(Proteome LabTM PF-2D). Result:There was an obvious difference 21 peaks between pre-chemoradiation and post-chemoradition; while there was an obvious difference 10 peaks between pretherapeutic patients and Non-patient population; and 4 peaks were found between post-treatment and Non-patient population. Conclusion:Serum proteinic markers that had diagnostic value and prognostic efficacy value might be found in serum of Kazak esophageal neoplasms patients.

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