The Effect of a Low Mclecular Weight Heparin on Chemotherapy Induced Activation of Hemostasis on the Ovarian Cancer
|Course||Obstetrics and Gynaecology|
|Keywords||Low molecular weight heparin Ovarian cancer Chemotherapy Fibrinogen D-dimer|
Objective: Determination of ovarian cancer patients during chemotherapy plasma fibrinogen and D-dimer level , the study chemotherapy before the application of a single dose of low molecular weight heparin on coagulation of ovarian cancer at the same time , provide a theoretical basis for the clinical prevention of thrombosis . Methods: 30 cases of ovarian cancer patients with chemotherapy alone , 20 cases of ovarian cancer patients is chemotherapy LMWH group were detected before chemotherapy and after chemotherapy 1h, 24 h, 48 h plasma fibrinogen and D- dimer content . Plasma fibrinogen was measured by the Clauss method , D-dimer immunogold penetration method . Results: 1. Chemotherapy group 1 h after chemotherapy , 24 h , 48 h plasma fibrinogen levels were lower than before chemotherapy , 24 h after chemotherapy compared with chemotherapy before , the difference was significant ( P = 0.0001 ) , 1 h and 48 h plasma fibrinogen levels after chemotherapy compared with chemotherapy before , the difference was not significant ( P = 0.527 and P = 0.385 ) . D-dimer levels were significantly higher than before chemotherapy , after chemotherapy, 24 h , 48 h before chemotherapy , the differences were very significant (P = 0.0001 and P = 0.0001 ) , 1 h after chemotherapy before chemotherapy phase ratio, no significant difference ( P = 0.773 ) . (2) low molecular weight heparin group chemotherapy after chemotherapy 1h, 24 h, 48 h plasma fibrinogen levels also lower than before chemotherapy , which after chemotherapy 24 h, 48 h , compared with before chemotherapy , the differences were highly significant (P = 0.0001 and P = 0.0001 ) , 1 h after chemotherapy , compared with chemotherapy before , the difference was not significant ( P = 0.169 ) . D- dimer levels 1 h after chemotherapy , 24 h , 48 h before chemotherapy compared to no significant increase , the difference was not statistically significant . (P = 0.875, P = 0.754, P = 0.348) Conclusion : Ovarian cancer patients with varying degrees of abnormal coagulation and fibrinolytic systems , chemotherapy can promote coagulation and fibrinolysis in patients with ovarian cancer, elevated levels , before the application of a single dose of chemotherapy Low molecular weight heparin can inhibit the activation of coagulation .