Dissertation > Medicine, health > Surgery > Surgical operation > Processing before and after surgery and surgical complications

Fine perioperative heart rate regulation is the implementation of the premise and basis of myocardial protection

Author MiKeReYi·SaiMaiTi
Tutor ZhengHong
School Xinjiang Medical University
Course Anesthesiology
Keywords β -blockers Perioperative heart rate Myocardial protection Meta-analysis
CLC R619
Type Master's thesis
Year 2011
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Objective: To evaluate perioperative system fine heart rate regulation and β -blockers exert cardioprotective effects , to explore the perioperative myocardial protection and effective measures. Methods : Through a computer search, collected between 1999 to 2009 at home and abroad , on the evaluation of non-cardiac surgery perioperative myocardial protective effects of β -blockers in clinical randomized controlled trials (RCT), using the Cochrane Collaboration 's RevMan5.0 software system evaluation methods Meta-analysis for non-cardiac surgery perioperative fine with β -blocker heart rate regulation play myocardial protective effect correlation relevant evidence. Results: After a comprehensive search and screening included a total of 13 randomized controlled trials , a total of 11,590 cases of patients . Meta-analysis showed that the overall non-cardiac surgery patients with perioperative β -blockers reduce perioperative adverse cardiac event rate [P = 0.0001, odds ratio (OR) = 0.64,95% confidence interval (CI) = 0.50-0.80 ] , but the results of its analysis with significant heterogeneity (I2 = 57%); to heart rate 100 beats / boundaries will be divided into 13 groups of study is divided into two groups , the results show : Two heterogeneity disappeared ( 12 = 0% ) , and when the heart rate less than 100 beats / min , β receptor blockers and myocardial protective effect statistically significant between the [P lt; 0.00001, odds ratio (OR) = 0.37 0.81-1.59 ] . Conclusion: The results of this systematic review revealed application p blockers on perioperative myocardial protection is a must, but the regulation of heart rate alone can not achieve p -blockers should be the depth of anesthesia , volume therapy , combination therapy , and strict control of non- treatment factors common result.

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