Dissertation
Dissertation > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes

Comparison of Differences in Bone Mineral Density and Its Related Factors for Patients with Type 2 Diabetes Mellitus of Han, Uygur Nationalities in Xinjiang

Author ChengBoNing
Tutor ZhuZuo
School Xinjiang Medical University
Course Internal Medicine
Keywords Type 2 diabetes mellitus Bone mineral density Dual-energy X-ray absorptiometry Uygur, han nationality
CLC R587.1
Type Master's thesis
Year 2011
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Objective:To investigate the differences between bone mineral density and its’related factors of 233 patients with the type 2 diabetes mellitus, Through determine and compare BMD of Uygur with Han nationalities. Methods:Choose 40-70 years old Uygur male, female, the han nationality male, female in patients with type 2 diabetes of endocrine department in 2009.09-2010.09. They are divided into four groups. There are Uygur male group, Uygur female group, han nationality male group, han nationality female group, lumbar of L1-L4 and left femur’s Bone mineral density with four groups patients. They are determinated by Lexxos type dual-energy X-ray absorptiometry which produced by France DMX company(DEXA), and to be diagnosised osteoporosis. Statistics all the data as follows:①o compare with the basic data of Uygur male group, Uygur female group, han nationality male group, han nationality female group.②Statistic bone mineral density determination of Uygur male group, Uygur female group, han nationality male group, han nationality female group and measure mean, standard deviation, and make t test.③atients with type 2 diabetes taking BMD correlation with age, course of disease, Body mass index, menopause age, glycosylated hemoglobin, HbAlc, fasing plasma insulin Fins, fasting serum C-peptide calcium, insulin sensitivity index, Homeostesis Model Assessment-Insulin secretion index, HMOA-ISI, phosphor-nium, magnesium, albumin, alka line phosphatase, blood urea nitrogen, creatinine etc. Result:①There are not statistically significant that patients with T2DM, Uygur male group, Uygur female group, han nationality male group, han nationality female group between age, BMI, course of disease (P>0.05).②It was not statistically significant that glycosylated hemoglobin, HbAlc, fasing plasma insulin Fins, fasting serum C-peptide calcium, phosphonium, magnesium, albumin, alka line phosphatase, blood urea nitrogen, creatinine of Uygur patients compared with the han nationality patients of T2DM (P> 0.05).③It was not statistically significant that L1-L4 BMD of Uygur patients compared with the han nationality patients of T2DM are at the same age and course (P>0.05). It was statistically significant that L1 and L2 vertebral bone mineral density of Uygur male patients are higher than the han male nationality (P<0.05). It was not statistically significant that L1-L4 BMD of Uygur female patients compared with the han female nationality patients of T2DM (P>0.05). It was statistically significant that L1 vertebral bone mineral density of han female patients are higher than the Uygur female nationality (P<0.05). It was not statistically significant that BMD of left femur of Uygur patients compared with the han nationality patients of T2DM (P>0.05).④it was significantly negative correlation femur BMD of patients with type 2 diabetes with age(r=-0.378, P=0.000), and with course negatively correlated (r=-0.196, P=0.013), and it was a positive correlation with body mass index (BMI) (r=0.259, P=0.003) insulin sensitivity index (r=0.194, P=0.012) Homeostesis Model Assessment-ISI (r=0.262, P=0.002), and with HbAlc negatively correlated (r=-0.24, P=0.007). It was no relation with fasing plasma insulin Fins, fasting serum C-peptide calcium, phosphonium, magnesium, albumin, alka line phosphatase, blood urea nitrogen, creatinine. Age as the control factor, female in type 2 diabetes is regardless of menopause age. Conclusions:①It was not statistically significant that glycosylated hemoglobin, HbAlc, fasing plasma insulin Fins, fasting serum C-peptide calcium, phosphonium, magnesium, albumin, alka line phosphatase, blood urea nitrogen, creatinine of Uygur patients compared with the han nationality patients of T2DM (P>0.05).②It was not statistically significant that L1-L4 BMD of Uygur patients compared with the han nationality patients of T2DM are at the same age and course (P>0.05). It was statistically significant L1 and L2 vertebral bone mineral density of Uygur patients are higher than the han nationality (P<0.05). It was not statistically significant that L1-L4 BMD of Uygur female patients compare with the han female nationality patients of T2DM (P>0.05). It was statistically significant L1 vertebral bone mineral density of han female patients are higher than the Uygur female nationality (P<0.05).③It was significantly negative correlation femur BMD of patients with type 2 diabetes with age, and with course negatively correlated, and it was a positive correlation with body mass index (BMI), insulin sensitivity index, Homeostesis Model Assessment-ISI. and with HbAlc negatively correlated. It was no relation with fasing plasma insulin Fins, fasting serum C-peptide calcium, phosphonium, magnesium, albumin, alka line phosphatase, blood urea nitrogen, creatinine. Age as the control factor, female in type 2 diabetes is regardless of menopause age.

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