Dissertation > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Thyroid disease > Hypothyroidism

Subclinical hypothyroidism and coronary heart disease

Author BaDengQiQiKe
Tutor WuGang;JinWeiJun
School Xinjiang Medical University
Course Internal Medicine
Keywords Subclinical hypothyroidism Coronary heart disease Multivessel disease
CLC R581.2
Type Master's thesis
Year 2011
Downloads 112
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Objective: To investigate subclinical hypothyroidism and coronary heart disease . Methods : 147 patients were divided according to the results of coronary angiography, coronary heart disease group 93 cases , 54 cases of the control group . All patients were selected except for pituitary tumors , cancer, familial hyperlipidemia and severe liver and kidney dysfunction , not taking amiodarone , lithium , metoclopramide , iodine , and other effects of domperidone thyroid function drugs nearly three months, the detection of free T3, free T4, thyroid-stimulating hormone (TSH), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C). LDL cholesterol (LDL-C). apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), recording characteristics of coronary artery disease , recording clinical data , through statistical analysis, the corresponding conclusions . Results: 1 CHD group and control group in age, sex, smoking prevalence of hypertension , diabetes prevalence was no significant difference ; 2 Univariate analysis of subclinical hypothyroidism correlated with coronary heart disease (0R = 2.112 OR95% CI1.102-4.546); 3. stratified according to whether , after suffering from hyperlipidemia subclinical hypothyroidism is still a risk factor for coronary heart disease ; 4 stratified according to whether hypertension subclinical hypothyroidism is still a risk factor for coronary heart disease ; 5 . Logistic regression analysis showed that subclinical hypothyroidism and other traditional risk factors for high blood pressure, triglyceride (TG) and coronary heart disease is closely related (P lt; 0.05 ) and its risk factors , and the high -density lipoprotein cholesterol (HDL-C) as a protective factor ; 6 does not vary with the number of diseased coronary branches and increased TSH levels increased , but the level of coronary lesion types with thyroid hormone levels increased and increased .

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