Dissertation > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetes

MODY family members Uygur serum metabolomics analysis and Nutrition Examination Survey

Author AiErKen·TaXiTieMuEr
Tutor PaTaMu·MoHeMaiTi;YiLiHaMuJiang·YiMaMu
School Xinjiang Medical University
Course Occupational and Environmental Health
Keywords MODY Metabolomics ~ 1H NMR Semi-quantitative food frequency method Dietary survey
CLC R587.1
Type Master's thesis
Year 2011
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Objective: To study the Uighur young adult diabetes (Maturity Onset Diabetes of the Young, MODY) family members of changes in the characteristics of serum metabolites; understanding of young adult diabetes Uighur family meals structural features. Methods: Kashi, Xinjiang Uygur collected four generations alive MODY families 2, 53 members of the general information collected and blood glucose, blood lipids, blood pressure and other indicators; using proton nuclear magnetic resonance spectroscopy (1H Nuclear Magnetic Resonance, 'H NMR) for each member of the serum metabolites were detected, the collected spectra data preprocessing, using principal component analysis (PCA), partial least squares discriminant (PLS-DA) and orthogonal partial least squares discriminant (OPLS- DA) analysis for data interpretation. Based on blood glucose, blood pressure, body mass index (Body Mass Index, BMI) divided into two groups on each level of metabolites were compared. By Pearson's correlation coefficient was significant difference test and two-dimensional spectroscopy techniques to determine each group differences in serum metabolic components; semi-quantitative food frequency questionnaire method Xinjiang Uygur four four generations alive young adult diabetes 112 family members of cross-sectional survey. Results: ① family members hyperglycemia group with normal glucose group compared blood metabolites, isoleucine, tyrosine content decreased, α-glucose, β-glucose levels increased and were statistically significant (P lt; 0.05) . ② family members with hypertension and normal blood pressure group compared blood metabolites, citric acid, inositol, 1 - methyl-histidine and tyrosine levels were reduced, and was statistically significant (P lt; 0.05). ③ normal BMI group with a high body mass index, blood metabolites group showed no significant difference. ④ MODY family members as the main food grains, poultry meat, milk, eggs, vegetables, fruits, beans and products amounted to less than the recommended amount, almost do not eat fish and shrimp; fat, protein and carbohydrate intake of the three major nutrients were exceeded , fats and proteins are mainly animal fats and proteins; calcium, vitamin C intake, phosphorus, potassium, sodium, magnesium, iron and other intake exceeded. Conclusion: ① MODY family members members hyperglycemia, hypertension, metabolic disorders TCA members of the body member of the body reflects the high blood sugar and muscle glycogen breakdown sugar source glycolysis decreased; while members of hypertension fat metabolism blocked. ② The Uighur MODY pedigree dietary unreasonable; MODY pedigree of the Uighur need to adjust diet or eating habits should be reformed.

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