Dissertation
Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension

Effect of Telmisartan and Benazepril on the Activity of Endothelial Lipase and Levels of Adiponectin in Patients with Mild Essential Hypertension

Author TanBiFeng
Tutor YangTianLun
School Central South University
Course Internal Medicine
Keywords telmisartan benazepril essential hypertension endothelial lipase adiponectin
CLC R544.1
Type Master's thesis
Year 2011
Downloads 12
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Aim:To determine the activity of the endothelial lipase and the levels of adiponectin in the serum of patients with mild essential hypertension, to analyze the relationship between the activity of the endothelial lipase and adiponectin and the blood pressure of patients with mild essential hypertension, and to observe the changes of the endothelial lipase activity and adiponectin concentrations in patients with mild essential hypertension treated with telmisartan or benazepril.Methods:68 patients with mild essential hypertension at the age of 30 to 70 were enrolled in the study. After 2 weeks of placebo treatment with the vitamin B1,68 patients were divided into two groups with 34 patients of each by single-blind method (telmisartan 40mg once a day or benazepril 5mg once a day). After 4 weeks treatment, those whose blood pressure was not well controlled were correspondently required to take telmisartan 80mg once a day and benazepril 10mg once a day. The treatment lasted 12 weeks. During this period the patients were followed once every two weeks (their blood pressure, status of medication and adverse reactions were recorded). After 12 weeks’treatment, the activity of the endothelial lipase and concentrations of adiponectin in the serum of patients were determined by ELISA (enzyme linked immune sorbent assay).Results:①There was not obvious difference except for the difference of their blood pressure between control and hypertensive group, suggesting that data had comparability in these two groups.②Before the treatment, the activity of the endothelial lipase in the serum of patients with mild essential hypertension was greatly higher than that of control group:(409.11±35.35)μg/L vs (319.78±17.31)μg/L, (P<0.01); and the concentrations of adiponectin in the serum of patients in the hypertension group were significantly lower than those of the control group:(5.13±0.59)mg/L vs(8.36±0.30)mg/L, (P<0.01). After 12 weeks treatment of telmisartan or benazepril, the activity of endothelial lipase in patients with mild essential hypertension was markedly decreased:(411.22±35.29)μg/L vs (330.51±20.36)μg/L (406.94±35.88)μg/L vs (357.14±27.96)μg/L, respectively (P<0.01); while the levels of adiponectin in hypertensive patients were significantly increased:(5.13±0.57) mg/L vs (8.28±0.24) mg/L, (5.12±0.61) mg/L vs (7.51±0.81) mg/L, respectively (P<0.01). After the treatment, both the decrease in the endothelial lipase activity and the increase in the concentrations of the adiponectin in telmisartan group were better than those of benazepril group (80.71±18.92μg/L vs 49.80±11.66μg/L; 3.15±0.48 mg/L vs 2.41±0.56 mg/L, respectively).③The SBP (systolic blood pressure)、DBP (diastolic blood pressure) and MAP(mean arterial blood pressure) of patients with mild essential hypertension were greatly decreased after treatment with telmisartan or benazepril (P<0.01). According to the analysis of multiple linear regression, the endothelial lipase activity in patients with mild essential hypertension was positively correlated with SBP and lower-density lipoprotein cholesterol (r=0.380, P=0.002; r=0.301, P=0.017, respectively), and was negatively correlated with high-density lipoprotein cholesterol, total cholesterol and adiponectin (r=-0.395, P=0.001; r=-0.330, P=0.008; r=-0.282, P=0. 025).Conclusion:①The activity of the endothelial lipase was increased and the concentrations of the adiponectin were decreased in patients with mild essential hypertension.②The activity of the endothelial lipase in patients with essential hypertension was positively correlated with systolic blood pressure and lower-density lipoprotein cholesterol, and was negatively correlated with their high-density lipoprotein cholesterol, total cholesterol and adiponectin.③Both of telmisartan and benazepril could decrease the endothelial lipase activity and increase the adiponectin levels in patients with mild essential hypertension, but telmisartan had better effects.

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