Dissertation
Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Heart disease > Myocardial diseases

Two Cases of Takotsubo Cardiomyopathy

Author PangJie
Tutor FuGuoSheng
School Zhejiang University
Course Department of Cardiology
Keywords takotsubo cardiomyopathy stress-induced cardiomyopathy left ventricular apical ballooning syndrome broken heart syndrome Torsade de pointes Long QT syndrome
CLC R542.2
Type Master's thesis
Year 2011
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Background:Takotsubo cardiomyopathy is a newly described reversible cardiomyopathy, characterized by transient dyskinesis in the left ventricular mid segments with or without apical involvement and cardiac dysfunction precipitated by intense emotional or physical stress, mimicking acute myocardial infarction in patients without significant coronary disease when the angiography is done.Objective:Two cases are reported here, aiming at increasing general awareness about the diagnosis, pathogenesis, and therapies of this novel disease.Method:The linical data, from the index event to the follow-up, were collected of these two cases, combinded with the database search on the pubmed. to summarize the experience of diagnosis and therapy.Result:Takotsubo cardiomyopathy is typically characterized by the following:(1) acute onset of ischemic-like chest pain or dyspnea, (2) transient apical and midventricular regional wall-motion abnormality, (3) minor elevation of cardiac biomarkers, (4) dynamic electrocardiographic changes (either ST-segment elevation and/or T-wave inversion). (5) the absence of epicardial coronary artery disease. But apart from the classical manifestation, the spectrum of Takotsubo cardiomyopathy is quite wide, with significant individual variations in clinical pattern, such as Torsade de pointes we reproted. The short and long-term prognosis of these patients is benign with exception of cardiac shock or malignant ventricular arrhythmia, and often only requires supportive therapy.Conclusion:It is apparent that takotsubo cardiomyopathy mimic ST-segment elevation myocardial infarction, and thus it’s critical to make an differentiation between the two. As more becomes known about this syndrome and more physicians are aware of the disease, the incidence, pathogenesis, and specific preventative therapies will be ascertained.

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