Dissertation
Dissertation > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension

The Relationship between the Level of Homocysteine and Important Target Organs Damage in Essential Hypertension.

Author WangMei
Tutor ZhangHua
School Xinjiang Medical University
Course Geriatrics
Keywords essential hypertension homocysteine target organ failure
CLC R544.1
Type Master's thesis
Year 2011
Downloads 38
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Objective:To investigate the relationship between the level of homocysteine and important target organs damage in middle-aged and senile patients with essential hypertension.Methods:There were 155 middle-aged and elderly essential hypertensive patients (98 males and 57 females,average age 65.14±13.15).All hypertensive patients were divided into group 1 (normal homocysteine group),81 patients(43 males,38 females) and group 2 (high homocysteine group),74 patients(55 males,19 females). All patients received detections of blood lipid,fibrinogen, homocysteine,random urine albumin levels, 24 hour ambulatory blood pressure,echocardiography,the determination of creatinine clerance rate. Results: The incidence of cerebral infarction in high homocysteine group is significantly more than that in normal homocysteine group(P<0.01).Compare with normal homocysteine group, high homocysteine group showed a lower level of creatinine clearance rate (P<0.01). High homocysteine group of the left ventricular mass index was no significant difference between normal homocysteine group (P>0.05). Correlation analysis showed that the level of homocysteine was positively correlated with fibrinogen,creatinine,smoking,drinking(r=0.237, r=0.207, r=0.179, r=0.237,P<0.01), but the homocysteine does not have correlated with TG, TC, HDL-C,LDL-C(P<0.05).It was shown by multiple unconditional logistic regression analysis that high plasma concentration of homocysteine increased the risk of hypertension with cerebral infarction(P=0.001,0R=4.404).Conclusion:The level of homocysteine is one of the important independent risk factors of target organs damage in middle-aged and senile patient with essential hypertension.

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