The Relationship between the Level of Homocysteine and Important Target Organs Damage in Essential Hypertension.
|School||Xinjiang Medical University|
|Keywords||essential hypertension homocysteine target organ failure|
Objective:To investigate the relationship between the level of homocysteine and important target organs damage in middle-aged and senile patients with essential hypertension.Methods:There were 155 middle-aged and elderly essential hypertensive patients (98 males and 57 females,average age 65.14±13.15).All hypertensive patients were divided into group 1 (normal homocysteine group),81 patients(43 males,38 females) and group 2 (high homocysteine group),74 patients(55 males,19 females). All patients received detections of blood lipid,fibrinogen, homocysteine,random urine albumin levels, 24 hour ambulatory blood pressure,echocardiography,the determination of creatinine clerance rate. Results: The incidence of cerebral infarction in high homocysteine group is significantly more than that in normal homocysteine group(P<0.01).Compare with normal homocysteine group, high homocysteine group showed a lower level of creatinine clearance rate (P<0.01). High homocysteine group of the left ventricular mass index was no significant difference between normal homocysteine group (P>0.05). Correlation analysis showed that the level of homocysteine was positively correlated with fibrinogen,creatinine,smoking,drinking(r=0.237, r=0.207, r=0.179, r=0.237,P<0.01), but the homocysteine does not have correlated with TG, TC, HDL-C,LDL-C(P<0.05).It was shown by multiple unconditional logistic regression analysis that high plasma concentration of homocysteine increased the risk of hypertension with cerebral infarction(P=0.001,0R=4.404).Conclusion:The level of homocysteine is one of the important independent risk factors of target organs damage in middle-aged and senile patient with essential hypertension.