The Efficacy of Oresol and Midodrine Hydrochloride in the Treatment of Children with Vasovagal Syncope
|School||Central South University|
|Keywords||Vasovagal syncope Child Midodrine hydrochloride Oral rehydration salts Mechanism Treatment|
The purpose of tracing observation before the intervention of oral rehydration salts and midodrine hydrochloride, after syncope and symptoms of aura syncope, upright tilt test (HUTT) ??results and hemodynamic changes, explore oral rehydration salts and midodrine hydrochloride Children vascular fans go syncope (VVS) therapeutic effect. 2007-11 to 2008-10 Second Xiangya Hospital Children syncope specialist treatment or hospitalization 6 to 17 years old (average 11.21 ± 3.13 years), 48 patients with unexplained syncope (UPS) or presyncope HUTT positive VVS children sub-health education group (n = 10), oral rehydration salts group (n = 23), midodrine hydrochloride group (n = 15) three groups, according evaluate the efficacy of the HUTT results. After 6 months of treatment, such as syncope or syncope the harbinger of onset of the withdrawal and continue to follow-up evaluation of children with syncope and presyncope recurrence rate, adverse drug reactions, and before and after the intervention hemodynamic changes using the statistical software SPSS 11.5 statistics Analysis. Results ① the HUTT. Seroconversion rate in the health education group, the group of oral rehydration salts and hydrochloric midodrine group were 20.0% (2/10), 60.9% (14/23) and 80.0% (12/15), including hydrochloric meters the monarch group and oral rehydration salts group was significantly higher than the health education group (P <0.05), the the hydrochloric Mido the Jun group and oral rehydration salts group difference was not statistically significant (P> 0.05). ② followed up for 6 to 12 months, syncope and syncope the aura recurrence rate in the health education group, oral rehydration salts group, midodrine hydrochloride group were 60% (6/10), 52.2% (12/23) and 13.3% ( 2/15), midodrine hydrochloride group was significantly lower than the first two groups (P <0.05), the health education group, and oral rehydration salts group difference was not statistically significant (P> 0.05). (3) three groups before and after the intervention supine blood pressure and heart rate difference was not statistically significant (P> 0.05); hydrochloric Mido the Jun group intervention after tilt starting with basic supine heart rate and blood pressure difference was significantly reduced (P <0.05) . Conclusion ① midodrine hydrochloride and oral rehydration salts intervention more effective than health education alone treatment for VVS children. VVS children can prevent syncope episodes ② health education and treatment of oral rehydration salts to some extent, but midodrine hydrochloride therapy can significantly reduce the VVS patients with syncope recurrence. The ③ midodrine hydrochloride is not to change the the VVS children's foundation supine heart rate and blood pressure, and no special adverse reactions. The ④ midodrine hydrochloride can reduce the hemodynamic changes in body position changes, improve the upright intolerance symptoms. The above tips basic measures of health education and oral rehydration salts to treat VVS children supplemented midodrine hydrochloride therapy can enhance the effect of their intervention, and can be safely and effectively used in recurrent syncope episodes of VVS children.