Dissertation
Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology > Chinese medicine Experimental Pharmacology

Punta grass Chubi decoction on serum inflammatory factors CIA Experimental Study on Effects

Author TianXinZuo
Tutor LiuChunJing
School Xinjiang Medical University
Course Chinese medical science
Keywords Punta grass soup Chubi Collagen-induced arthritis Interleukin -1β Tumor necrosis factor -α Prostaglandin E2
CLC R285.5
Type Master's thesis
Year 2011
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Objective: To observe Chubi Tang Peng grass type Ⅱ collagen -induced arthritis (CIA) in serum IL-1β, TNF-α and PGE2 inflammatory factors and mechanisms. Methods: 10 rats were randomly selected as a control group , and the remaining 50 build collagen Ⅱ -induced rheumatoid arthritis were randomly divided into traditional Chinese medicine of high , medium and low dose group , triptolide group and model group , and triptolide group as a positive control group was observed 6 weeks to evaluate Punta grass Chubi decoction on CIA rats double rear foot joint swelling , joint pain index dual rear foot as well as the inhibition of body weight and peripheral serum IL-1β, TNF- α and PGE2 levels. Results: Compared with model group , the treatment groups significantly inhibited rat paw edema after dual degree (P lt; 0.01, P lt; 0.05) and double rear foot joint pain index (P lt; 0.01); medicine high, dose group could significantly improve weight gain (P lt; 0.01, P lt; 0.05); each treatment group improved serum IL-1β, TNF-α and PGE2 levels were significantly better than the model group (P lt; 0.01), which Chinese medicine dose group IL-1β, TNF-α levels significantly better than the inhibition of triptolide group (P lt; 0.05), high dose group decreased PGE2 levels better (P lt; 0.05). Conclusion : Punta grass soup Chubi CIA rat paw swelling inhibits and reduces joint pain index , effectively improve the symptoms of arthritis in CIA rats , and its mechanism may be associated with reduced serum proinflammatory cytokines IL-1β, TNF-α and related to the level of PGE2 , worthy of further research and development is a pure traditional Chinese medicine .

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