Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology

Clinical Observation on YunPi Jiangtang Tongmai Tang to Treatment Diabetes with Coronary Heart Disease

Author ZhangWei
Tutor WangJiDi
School Shandong University of Traditional Chinese Medicine
Course Chinese medical science
Keywords diabetes mellitus with coronary heart disease YunPi Jiangtang tongmai the Clinical research
CLC R285
Type Master's thesis
Year 2011
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Objective: To observe the effect of "Yun Pi Jiang tang tongmai tang" on improving the clinical curative effect diabetic patients with coronary heart disease,and to erplore its mechanism of action , in order to lay the foundation for further research.Methods: clinical accord with western medicine diagnosis of type 2 diabetes mellitus and coronary heart disease, angina and conforms to the Pi Xu Tang Zhu patients 48 cases were randomly divided into two groups. Both groups based in diabetes education, reasonable treatment (diabetes, diabetes mellitus dietary) movement, under the same condition. Group A (control group) : diabetic coronary heart disease western conventional treatment: l, reduce blood glucose: metformin hydrochloride HuanShiPian 0.5 g q n, 2, coronary heart disease, angina conventional treatment: isosorbide mononitrate 20mg the bid, aspirin tablet enteric-coated metformin hydrochloride 100mg q d, did fenofibrate 0.1 g tablet tid, tartaric acid metoprolol 25mg the bid (depending on patients tablet heart rate, blood pressure, etc, adjust its dosage). Group B (in western medicine treatment group) : diabetic coronary heart disease on the basis of conventional treatment with unclogged arteries take shipped spleen glucose-lowering square, the water frying uniform, daily, morning and evening twice a dose of drug. Portion Both groups are treatment cycle for 28 days. Two groups of patients before and after treatment observe clinical symptoms, fasting plasma glucose (FPG) and 2-hr plasma glucose (2hPG), total cholesterol TG, triglycerides TC, high-density lipoprotein cholesterol HDL, low density lipoprotein LDL index changes.Results: clinical observation results show that 4 weeks after treatment, the treatment group in the control group total curative effect, TCM symptoms TCM single symptoms, angina pectoris curative effect, electrocardiogram curative effect, nitroglycerin minus stop rate quite, significant difference (P < 0.05). In treatment group and control group, before treatment and therapy 2hPG after comparison, FPG difference (P < 0.05). The control group and the treatment group compared after treatment, 2hPG a statistically significant FPG, (P < 0.05). Before and after the treatment group of patients in cholesterol, glycerine three cool and low density lipoprotein level all have declined, high-density lipoprotein were increased by t-test, all have statistically significant (P < 0.05), the treatment group compared with controls, the treatment group by t-test, of cholesterol, triglyceride and low density lipoprotein reduced significantly better than the control group (P < 0.05), and the rise of high-density lipoprotein (HDL) no significant differences between groups (P > 0.05).Conclusion: the results show the YunPi Jiangtang tongmai tang can effectively improve the type 2 diabetic patients with coronary heart disease, angina syndromes, angina symptoms, electrocardiogram, improve nitroglycerin stop minus rate. Has a significant anti-myocardial ischemia effect, improve patients’ blood lipid metabolism, correcting the metabolic disorder, and has adjust sugar metabolism function, can be assisted fasting blood glucose, insulin effective control blood sugar 2-hr. theYunpi Jiangtang tongmai Fang treatment of this disease clinical efficacy precise, clinical application safe and reliable.

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