Dissertation > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Male genital diseases > Prostate disease

The Relationship Study of Metabolic Syndrome with Benign Prostate Hyperplasia

Author LiuYingJie
Tutor GaoHaiQing
School Shandong University
Course Geriatrics
Keywords metabolic syndrome benign prostate hyperplasia coronary heart disease
CLC R697.3
Type Master's thesis
Year 2009
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Objective:The study is to investigate the relationship between metabolic syndrome(MS) and benign prostate hyperplasia(BPH) and to identify clues to the etiology of BPH for the sake of common pathophysiologic mechanism.Methods:Our material comprised a consecutive series of 300 outpatients with lower urinary tract symptoms(LTTUS) with or without manifestations of the metabolic syndrome.Took the medical record and questionnaire of international prostate symptoms score(IPSS).Data on blood pressure, waist and hip measure,body height and weight were collected and body mass index(BMI) and waist/hip ratio(WHR) were calculated.Blood samples were drawn from fasting patients to determine fasting blood glucose(FBG), cholesterol(TC),triglycerides(TG),HDL and LDL-cholesterol,the specific prostate antigen(PSA).The prostate gland volume(PV) was determined using ultrasound.Measured maximum flow rate(Qmax) using urodynamic machine.Complete statistics and investigate the relations hip of metabolic syndrome(MS) and benign prostate hyperplasia(BPH).Results:Transform the indexes of benign prostate hyperplasia into normal datas(PV1~2=logPV,PSAx=logPSA,Qmaxx=logQmax,IPSSy~2=IPSS).We find the indexes significantly positively correlate with each other,but negatively with Qmax.The prostate gland volume correlates positively with the body weight(r=0.122;P<0.05),systolic blood pressure(SBP) (r=0.171;P<0.05),fasting blood glucose(FBG),(r=0.100;P<0.05); triglycerides(TG)(r=0.133,P<0.05) and hidtory of BPH(r=0.131;P<0.05) and negatively with HDL-cholesterol(r=-0.118;P=0.009).The regression equation:PVI=0.154 SBP+0.120 BPH史-0.090 HDL+0.081 TG+0.080 body weight(F=4.359;P=0.001);an exponential function.PSAx= -0.227HDL,(P<0.001),an exponential function.Qmaxx=-0.136AGE-0.135LDL -0.085waist,(P=0.022<0.02),AGE、LDL-C、waist circumstance is in exponential function with Qmax;Qmax in Diabetes Mellitus is lower in than the other group(1.0414±0.217 1.0441±0.232),(t=3.056,P= 0.0016<0.05).AGE and HDL is partial correlative with IPSS.The IPSS is higher in hypertension(HP)group than in the other(13.03±7.304/11.26±6.883)(t=-2.056,P<0.05).The CHD patients with a larger PV,suffering the lower urinary tract syndrome(LUTUS),live a bad life.Comparing with the contrast,the CHD group is more larger in PV,lower in Qmax and higher IPSS score,which indicates the correlation with BPH.The indexes of metabolic syndrome is significantly relationship with BPH.The results suggest that BPH is a facet of the metabolic syndrome and that BPH patients may share the same metabolic abnormality of a defective insuli n-mediated glucose uptake and secondary hyperinsulinemia as patients with the metabolic syndrome.NIDDM(non-insulin dependent diabetes mel litus), treated hypertension,obesity,low HDL-cholesterol levels and high insulin levels constitute risk factors for the development of BPH.The findings generate a hypothesis of a causal relationship between high insulin levels and the development of BPH.In a clinical setting,the findings of the present report suggest that,in any patient presenting with BPH,the possible presence of NIDDM,hypertension,obesity,high insulin and low HDL-cholesterol levels should be considered.Conversely, in patients suffering from these conditions,the possibility of a clinically important BPH should be kept in mind.

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