Dissertation
Dissertation > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases

Study on the Effects of the Mothod of Invigorating the Spleen and Kidney Detoxification and Vigoration of Blood Circulation on Early Diabetic Nephropathy and Flt-1 Expression on Rat Models

Author GuoChunFang
Tutor QianQiuHai
School Shandong University of Traditional Chinese Medicine
Course Chinese medical science
Keywords Spleen and kidney, the detoxification Huoxuetongluo Law Diabetic nephropathy Comprehensive intervention Ultrastructure Flt-1
CLC R259
Type Master's thesis
Year 2011
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Objective: This paper aims to previous studies , explore spleen and kidney, detoxification the Therapeutic Huoxuetongluo , sugar Shen Ning square with comprehensive clinical intervention role of Chinese medicine , ear early diabetic nephropathy , and is to explore Tangshen Ning treatment of diabetic nephropathy mechanism . Method: 1 . Clinical research : determine the early diagnosis of diabetic nephropathy and Response Evaluation Criteria , main Tangshen Ning Fang , with the method of Chinese medicine , ear and other comprehensive intervention on early diabetic nephropathy , and set the comparison group , using a large sample , prospective, randomized controlled study methods , quality of Life Scale early signs and symptoms of patients with diabetic nephropathy , urinary albumin as the primary efficacy endpoint , clinical observation of safety indicators , and results analysis . Experimental study : triple modeling method ( unilateral renal removal of a small dose of high sugar and fat STZ injection ) the establishment of early diabetic nephropathy rat model , after 12 weeks of drug intervention , biochemistry, electron microscopy , immunohistochemistry of sugar Shen Ning rat model of vital signs , renal function , renal pathology and ultrastructure and Flt-1 immunohistochemical expression . Results: 1 . Clinical research : the comprehensive treatment of Jianpibushenjiedu Huoxuetongluo law not only effective in improving the signs and symptoms of the patients with diabetic nephropathy , improve early renal function ( P lt; 0.05 ) , lower blood glucose and lipid level ( P lt ; 0.05) , but also improve the quality of life of patients , the total effective rate of 90.6% , the indicators are better than the comparison group . Experimental study : triple modeling method can successfully copied the model of early diabetic nephropathy . Tang Shen Ning can significantly improve the survival of the state of the model in rats , early renal function , blood glucose , blood lipids and hemorheology , at the same time also has significant effect on renal pathology and ultrastructural changes , but also to reduce kidney tissue Flt-1 immunohistochemical expression . The conclusion : Jianpibushenjiedu Huoxuetongluo method of early diabetic nephropathy comprehensive intervention effect ; spleen and kidney, detoxification Huoxuetongluo Therapeutic composition Tangshen Ning Fang efficacy exact . Sugar kidney would rather by improving blood sugar , blood lipids and hemorheology protect renal function and kidney pathological changes of the structure has a protective effect , it is worth further study .

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