The Clinical Research of Modified Zhi Bai Di Huang Decoction Combined with Glucocorticoid in the Treatment of Primary Nephrotic Syndrome Pattern of Yin Deficiency with Effulgent Fire
|School||Shandong University of Traditional Chinese Medicine|
|Course||Traditional Chinese Medicine|
|Keywords||The flavored Zhibai yellow soup Primary nephrotic syndrome Yin Huowang certificate Clinical observation|
Objective: To observe I The Modified know Bai Di Huang Tang clinical efficacy for the treatment of primary nephrotic syndrome Yin Huo card to further explore the advantages and feasibility of combination therapy with primary nephrotic syndrome, in Western-based treatment for Western combined provide a scientific basis for the treatment of primary nephrotic syndrome and a safe and effective treatment method. Methods: This study primary nephrotic syndrome meets the Chinese Yin Huo card 60 cases, were randomly divided into 2 groups, 30 patients in each treatment group and the control group. Control group to immune suppression, lowering proteinuria Western base treatment group plus Western medicine basic treatment with the flavored Zhibai yellow soup, the course of two months. Clinical symptoms, signs and laboratory tests indicators of change, and the symptoms and signs of quantitative score, to make the efficacy evaluation. The results: 1 flavored know Bai Di Huang Tang combined with western medicine treatment group completely alleviate the eight cases, significantly ease the 12 cases, partial remission of 7 cases, 3 cases, total have efficiency of 90%; comparison group completely alleviate the six cases, significantly ease the eight cases, partial remission in 6 cases, 10 cases, the total efficiency of 67%; two groups had significant difference (P lt; 0.05) 2 TCM total symptom score comparison: After treatment, TCM symptom scores were significantly reduced, the same group after treatment, a significant difference compared with before treatment; very significant difference between the two groups TCM symptom score after the end of treatment, treatment group was significantly less than that of the control group (P lt; 0.01) 3 TCM symptom improvement, the two groups of patients with clinical symptoms after treatment and before treatment significantly improved (P lt; 0.05 or P LT; 0.01). The end of treatment, the treatment group improved in patients with dry mouth and throat, Yin Huo-wang clinical signs and symptoms of skin boils, swollen sores, night sweats, five upset hot than the control group. 4 before and after treatment in 24-hour urine protein comparison: both groups to reduce the 24-hour urine protein, and the treatment group than the control group (P lt; 0.05). Serum albumin in the two groups before and after treatment comparison: both groups increased serum albumin, and the treatment group than the control group (P lt; 0.05). 6 comparison of the two groups before and after treatment lipids: the two groups can lower cholesterol, triglycerides and low-density lipoprotein, and the treatment group than the control group (P lt; 0.05). Renal Function: 7 two groups before and after treatment renal function before and after treatment showed no significant difference (P gt; 0.05) 8 Security Analysis: Modified Bai Di Huang Tang said the patient's blood, urine, stool, liver function, electrocardiogram had no adverse effects in the clinical treatment process using the side no adverse phenomenon, indicating that The flavored Zhibai yellow soup is safe and effective. Conclusion: Modified Zhibai yellow soup with Western medicine therapy on primary nephrotic syndrome wang permit curative effect, can significantly improve the urinary protein, serum albumin, serum lipid levels; significant improvement in patients with dry mouth and throat, skin boils, swelling sore, night sweats, five upset hot Yin Huo clinical symptoms and signs; and there are obvious advantages (P lt; 0.05 or P LT; 0.01) than the control group. Modified know Bai Di Huang Tang is safe and effective in clinical applications, is one of the better methods for the treatment of primary nephrotic syndrome Yin Huo card, showing the advantage of Integrative Medicine treatment of this disease, whether it helps to improve the original onset nephrotic syndrome remission rate needs to be further study of a large sample.