Dissertation
Dissertation > Medicine, health > Oncology > Genitourinary tumors > Male genitalia tumors > Prostate cancer

Isoflavone intake and the risk of breast and prostate cancer Meta-analysis

Author FengChuanYue
Tutor ZhuJunDong
School Third Military Medical University
Course Nutrition and Food Hygiene
Keywords Soy Isoflavones Breast Cancer Prostate Cancer Meta-analysis
CLC R737.25
Type Master's thesis
Year 2010
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Objective: Meta-analysis approach to home and abroad on isoflavone intake and the risk of breast and prostate cancer case-control study conducted a comprehensive analysis of relevant literature to determine whether soy isoflavone intake and breast cancer and prostate cancer-related . Methods: From 1999 to 2009 at home and abroad published on soy isoflavones and soy food intake and breast cancer risk factors for prostate cancer analytical epidemiological literature. Using the RevMan 4.2 software, according to the literature heterogeneity test results for the fixed effects model or random effects model and cumulative Meta-analysis Meta-analysis. Inclusion criteria for the different results of a sensitivity analysis, using funnel plots and the loss factor of safety assessment of publication bias. Results: The inclusion of the literature concerning soy isoflavones and breast cancer were 13 domestic and foreign literature, including foreign literature 11, domestic literature 2, the cumulative cases of 6328 people, 8987 people were combined OR = 0.79, 95 % confidence interval (0.66,0.94), soy isoflavones and prostate cancer on the relationship between literature 8, foreign literature 7, domestic literature 1, the cumulative cases 1372, 4330 people were combined OR = 0.52, 95% CI (0.34,0.79). Isoflavone intake and breast cancer and prostate cancer Cumulative Meta-analysis showed that, as the sample size increases, OR point estimates and 95% confidence interval stabilized and there is a good trend. According to this study the characteristics of the information collected on the different risk factors were carried out sensitivity analysis and the results were similar to the original, the total sample supported the findings, conclusions stable and reliable. The study basically symmetrical funnel plot factors, loss of a safety factor of ten in the 5k or more, suggesting that the publication bias were well controlled. Conclusions: 1. Soy isoflavone intake and breast cancer risk associated recurrent intake of soy isoflavones can reduce the risk of breast cancer, is a protective factor for breast cancer. 2 soy isoflavone intake and prostate cancer risk associated recurrent intake of soy isoflavones can reduce the risk of prostate cancer, prostate cancer is a protective factor. 3 Cumulative Meta-analysis results reflect the soy isoflavone intake and breast cancer and prostate cancer associated with the dynamic changes of intensity, suggesting that soy isoflavone intake and breast cancer, and prostate cancer risk relationship is relatively stable. 4 Sensitivity analysis and publication bias recognition results indicate that this Meta-analysis results are stable, reliable, and a true reflection of soy isoflavone intake and the risk of breast and prostate cancer epidemiological findings.

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