Research of Relationship between "Similarity of the Phenomenon of Alcohol Withdrawal" and Benign Symmetric Lipomatosis
|Course||Department of Otolaryngology - Head and Neck Surgery|
|Keywords||Benign symmetric lipomatosis Alcohol withdrawal syndrome Alcoholism γ-aminobutyric acid Isoflurane|
Benign symmetric lipomatosis is a rare benign disease of the head and neck, the etiology of the disease has not yet entirely clear, but it is certain that a large number of alcohol-related disease and long-term. Benign symmetric lipomatosis patients through surgical approach to achieve recovery dysfunction and the purpose of cosmetic plastic surgery, but severe postoperative complications of the disease in some patients, in addition to the obvious neck swelling compression of the trachea affect the respiratory line static suction combined with general anesthesia fully awake after significant psychiatric symptoms, such as facial flushing, delirium, restlessness, excitement, then questioning the wrong answer, no purpose grip, mydriasis, bilateral upper extremity tremor, elevated blood pressure and sinus tachycardia, highly concurrent heart, brain dysfunction, endangering the lives of patients, the mortality rate was high. Therefore, to explore and study patients with benign symmetric lipomatosis causes and pathogenesis of postoperative Class alcohol withdrawal phenomenon \clinical treatment and early prevention of the disease has a certain practical significance. Benign symmetric lipomatosis key to long-term heavy alcohol abusers preoperative suddenly stop drinking after admission or a more substantial decrease 3-4 days after the amount of alcohol, alcohol withdrawal syndrome in some patients, but some patients with alcohol no obvious symptoms of alcohol withdrawal, but the line static suction combined with general anesthesia fully awake after significant withdrawal symptoms similar to alcohol withdrawal, which we have proposed a new hypothesis, \withdrawal phenomenon. \Long-term, a large number of alcoholics stop drinking does not appear significant withdrawal symptoms, similar to alcohol withdrawal symptoms after inhalation combined with general anesthesia fully awake after 1 day. Occurs regardless of the symptoms of alcohol withdrawal and the direct effect of the anesthetic drugs. The mechanism may be related to a variety of neurotransmitters in the body related to the rise. Experiments confirmed that inhalation combined with general anesthesia in clinical concentrations of isoflurane, ether inhibit the degradation of GABA, GABA accumulation in the blood rises. May be due to alcohol withdrawal syndrome pathogenesis of elevated GABA levels in the blood, we speculated that in patients with benign symmetric lipomatosis line \preoperative long-term heavy alcohol and inhalation related to certain inhaled anesthetics used in general anesthesia, when the anesthesia is fully awake, GABA levels in the blood, which further induced or wake-occurrence of alcohol withdrawal phenomena that occur \In this regard, for the long-term heavy alcohol abuse underwent inhalation anesthesia completely sober Class alcohol withdrawal phenomenon \preoperative long-term heavy alcohol abuse history, which we benign symmetric lipomatosis underwent inhalation combined with general anesthesia fully awake after alcohol withdrawal phenomenon \suction certain inhaled anesthetics used in general anesthesia. In this paper, we first proposed a \Objective To investigate the benign symmetric lipomatosis and long-term heavy alcohol abusers suction line static fully awake after surgery and general anesthesia \This article by inhalation general anesthesia fully awake after alcohol withdrawal phenomenon \general anesthesia fully awake after facial flushing, delirium, agitation, excited much questioning the wrong answer, no purpose grip, mydriasis, bilateral upper extremity tremor, elevated blood pressure, sinus tachycardia, sympathetic excited symptoms and pathogenesis, and through our successful treatment to improve the cure rate of the disease in the future of post-operative complications, and played a certain role in guiding the clinical work. Methods 15 healthy Wistar male rats do alcohol withdrawal and anesthesia animal model, in which the control group of five, alcohol group (n = 10), anesthesia animal models of isoflurane underwent last 10 alcoholic rats model drinking 72 hours inhalation anesthesia. Consumption of alcohol (52% the China Luzhou Co., Ltd.), daily from 9:00 am to alcohol group (10ml/kg) Rats were intragastrically four weeks. The control group was given the same dose of saline. 4 weeks respectively in the alcohol group and the control group rats orally last drinking and drinking water 30 hours, 72 hours of observation of alcohol withdrawal syndrome score and 2 ml peripheral venous blood collected, the control group and the anesthesia group row isoflurane anesthesia awake after 15 minutes, 60 minutes to observe the alcohol withdrawal syndrome, and rate and peripheral venous blood collected 2 ml, 3000 rev / min 20 minutes after the serum by centrifugation, using enzyme-linked immunosorbent assay in serum γ-amino butyric acid (GABA ) concentration. Alcohol withdrawal syndrome score using alcohol-dependent rats withdrawal behavioral signs and audiogenic seizures ratings standard score (Table 3.1). Results the alcoholic rats alcohol withdrawl GABA concentration in the serum of 30 hours of alcohol than the control group, P lt; 0.05, the difference was statistically significant; 72 hours after alcohol withdrawal, alcohol serum GABA concentration similar to the control group, P gt; 0.05, no statistical difference; anesthesia group rats were anesthetized and awake GABA concentration in the serum 15 minutes compared with the control group, P lt; 0.05, significant difference; anesthesia group rats were anesthetized and awake 60 minutes anesthesia group serum GABA concentrations similar to the control group, P gt; 0.05, no statistical difference; alcoholic rats alcohol withdrawal after 30 hours of alcohol group withdrawal scores than the control group, P lt; 0.05, the difference was significant; 72 hours after alcohol withdrawal alcohol group withdrawal scores similar to the control group, P gt; 0.05, not statistically significant. Anesthesia groups anesthesia awake after 15 minutes of anesthesia group withdrawal scores than the control group, P lt; 0.05, the difference was statistically significant; anesthesia awake after 60 minutes of anesthesia group withdrawal scores similar to the control group, P gt; 0.05, no statistically significant. Conclusions. Benign symmetric lipomatosis and long-term heavy alcoholics line inhalation combined with general anesthesia completely sober after class alcohol withdrawal phenomenon \alkoxy inhaled anesthetic agents. Benign symmetric lipomatosis and long-term heavy alcoholics line inhalation combined with general anesthesia fully awake after Class alcohol withdrawal phenomenon pathogenesis of postoperative blood GABA levels related.