Dissertation
Dissertation > Medicine, health > Obstetrics and Gynaecology > Gynecology > Other diseases of the female genital > Ovarian disease

The Comparison of Serum Endocrine, Metabolic Status and Fat Factor between Obese and Non-obese Adolescent Patients with Polycystic Ovary Syndrome

Author LiSuFang
Tutor ZhangZhiFen
School Zhejiang University
Course Clinical
Keywords Polycystic ovary syndrome Adolescence Leptin Apolipoprotein A1 Apolipoprotein B Adiponectin Insulin resistance DHEA sulfate
CLC R711.75
Type Master's thesis
Year 2010
Downloads 253
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Objective: To compare obese and non-obese adolescents with polycystic ovary syndrome (adolescents WITH polycystic ovary syndrome, PCOS) patients with reproductive endocrine, glucose and lipid metabolism and fat in the blood factor level differences to explore the clinical features of adolescent patients with PCOS, reproductive endocrinology, glycolipids metabolic characteristics and pathogenesis. Methods: adolescent PCOS patients 73 cases, record the patient's height, weight, waist and hip circumference were measured based reproductive hormones, fasting blood glucose, blood lipids, blood insulin, blood leptin (leptin), serum adiponectin (adiponectin), parallel glucose tolerance test (OGTT). Results: 1 non-obese adolescent PCOS patients blood yellow body generates hormone levels (LH) and yellow body generates hormone / follicle stimulation hormone (LH / FSH) were significantly higher than the obese group (17.69 ± 12.10 vs 12.25 ± 7.43 IU / L, P <0.05; 3.18 ± 1.84 vs 2.19 ± 1.24, P lt; 0.01); the obese group blood dehydroepiandrosterone sulfate (DHEA) was significantly higher than non-obese group (307.43 ± 104.54 vs 257.12 ± 78.73ug/dl P <0.05) .2 obese group fasting blood insulin levels and insulin resistance index (HOMA-IR) were significantly higher than non-obese group (17.03 ± for 10.69 ± 8.94vs 21.38uU/mL P lt; 0.05; 4.03 ± 2.17 vs 2.43 ± 4.81, P lt; 0.05) .3 obese group blood triglyceride (TG), low density lipoprotein (LDL), apolipoprotein B levels were significantly higher than non-obese group (1.67 ± 0.86 vs 0.91 ± 0.48 mmol / L, P lt; 0.01; 2.83 ± 0.91vs2.47 ± 0.63mmol / L, P lt; 0.05; 0.91 ± 0.27vs0.77 ± 0.24g / L, P <0.05); blood high-density lipoprotein (HDL ), apolipoprotein A (ApoA-1) concentration was significantly lower than non-obese group (1.26, ± 0.30vs1.63 ± 0.32 mmol / L, P <0.01; 1.30 ± 0.31 vs 1.56 ± 0.46 g / L, P lt; 0.01 ) HDL and Apo A-1 was positively correlated (r = 0.465, P = 0.000), LDL and apolipoprotein B were positively correlated (r = 0.831, P = 0.000). 4 obese group serum leptin levels were significantly higher than non-obese group (18242.158 ± 7727.2082 8155.6531 ± 5188.5698pg/ml P lt; 0.01), serum adiponectin was significantly lower than non-obese group (3199.233 ± 1360.242 vs 5545.442 ± 2928.996ng/ml, P lt; 0.01). Serum leptin levels and BMI was positively correlated (r = 0.656, P = 0.000), serum adiponectin levels and BMI were negatively correlated (r = 0.417, P = 0.000), serum leptin and adiponectin with HOMA-IR without significant correlation. Serum TG and serum leptin was positively correlated (r = 0.345, P = 0.002), serum TG and serum adiponectin was negatively correlated (r = 0.311, P = 0.006). Conclusion: The obese adolescent PCOS patients in vivo glucose and lipid metabolism abnormalities compared with non-severe obesity, serum leptin levels were significantly increased serum adiponectin levels were significantly lower. Therefore it is necessary to conduct a comprehensive assessment of adolescent PCOS patients, and to intervene to combat long-term complications.

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