Initianal Study of TCM Syndrome Distribution about Minimal Residual Disease in Acute Leukemia
|School||Guangzhou University of Traditional Chinese Medicine|
|Course||Chinese medical science|
|Keywords||Minimal residual disease Blood and body fluids dialectical Syndrome distribution|
Background leukemia is one of China's top ten high incidence of malignant tumors, the incidence rate of approximately 2.76/10 000 With the development of modern medicine its clinical remission induction rate of 70% to 90%, but even reach the bone marrow of patients with complete remission, there are still considerable proportion of relapse, and how to prevent leukemia relapse so as to achieve the purpose to prolong survival or cure, is currently a hot research. Minimal residual disease (minimal residual disease MRD) is a major factor in leukemia relapse, the the MRD study is its key. Medicine, for MRD clinical mostly empirical treatment of one of the words in Treating MRD more from righting tonic, eliminate the vestiges of three aspects Fuzhengjiedu, TCM no unified clinical epidemiology research derived type as the basis, it is necessary to TCM syndromes of of unified clinical epidemiology research. The purpose of this subject by clinical epidemiological study statistics, initially identified the syndrome of minimal residual disease in Chinese medicine, to lay the foundation for TCM Treatment of MRD, lay the foundation for the Next TCM Treatment of the MRD standardization of clinical research. The method consists of a review of the literature, clinical epidemiological study both elaborate. Review of the Literature Research of minimal residual disease in Western medicine acute leukemia presented current research focus problem. Clinical research through clinical epidemiology survey of 180 cases from January 2005 to December 2009 Guangdong Provincial Hospital, Guangzhou Military General Hospital hematology ward hospitalization has been diagnosed with acute leukemia minimal residual disease patients, according to the results of the literature research and securities designate the reference standard, the design of acute leukemia minimal residual disease the TCM syndromes acquisition table, fill in the collection table, the use of the SPSS13.0 software that appears on 180 cases of acute leukemia patients with minimal residual disease by TCM symptom frequency analysis, and TCM syndrome diagnostic criteria type dialectical. Results of 180 patients with acute leukemia minimal residual disease in cases of distribution of TCM syndromes single symptom frequency languid highest, accounting for 93.3%, followed by spontaneous again, night sweats, appetite poor, limb heaviness; Tongue appears highest frequency for the tongue is pink with white, 25.6%, followed by the tongue is pink with yellowish, pale tongue fur dark yellowish, pale tongue edge with white fur, teeth marks; Pulse aspects, the highest frequency for pulse wiry, accounting for 23.9%, followed by the pulse was weak, weak pulse, slippery pulse string; TCM clinical the dialectic to Qiyinliangxu, accounting for 29.4%, followed by qi deficiency, qi deficiency and dampness, yin stasis and other 10 class syndrome type; deficiency mixed mainly accounted for 69.4% in terms of the actual situation class to 30.6%, deficiency syndrome, no purely empirical Qi Deficiency; clustering analysis after TCM syndromes, accounting for 47.2%, followed by Qi and damp Yun card, Qiyinliangxu, folder stasis each node, Qiyinliangxu wet stasis, blood deficiency folder stasis five type. Conclusion acute leukemia minimal residual disease is a \, followed by Qi and damp Yun certificate Qiyinliangxu stasis to Qiyinliangxu each node, Qiyinliangxu wet stasis stasis blood deficiency. The clinical resolution combining syndrome differentiation, the proposed plus syndrome type \. Preliminary MRD TCM syndrome type, common understanding of current practitioners of Chinese medicine. Limited cases sources are in the southern region, the small sample size, combined with TCM syndrome of subjective conclusion may be biased. Still need to continue to conduct a multi-center, large sample clinical epidemiological research before further establish the basic syndrome type of TCM Treatment of MRD.