Dissertation > Medicine, health > Internal Medicine > Digestive and abdominal diseases > Liver and gall bladder disease > Cirrhosis

Comparison of Clinical Characteristics of Patients between Viral Cirrhosis and Alcoholic Cirrhosis: A Retrospective Analysis

Author ZhouYongLi
Tutor DuanZhiJun
School Dalian Medical University
Course Internal Medicine
Keywords Liver cirrhosis Alcoholic cirrhosis Comparative study Retrospective analysis
CLC R575.2
Type Master's thesis
Year 2010
Downloads 201
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Objective: A comparative analysis of liver cirrhosis and alcoholic cirrhosis patients with clinical manifestations, complications, and prognosis, etc. There was thus to explore the different treatment of the two emphases, view from different angles targeted for effective prevention. Methods: April 2004 -2009 in May at the First Affiliated Hospital of Dalian Medical University, a clear diagnosis of cirrhosis of the medical records of patients on admission. 952 cases were enrolled in this study meet the requirements of clinical data in patients with cirrhosis, including liver cirrhosis (viral cirrhosis, VC) 656 patients with alcoholic cirrhosis (alcoholic cirrhosis, AC) 198 patients with alcoholic hepatitis virus mixed factors induced cirrhosis (AC VC) 98 cases Cirrhotic patients compared three groups of gender, age, disease duration, clinical manifestations, liver function, complications, and direct cause of death and other indicators of diversity. 1 In all cirrhosis, VC predominant portion (63.66%), which accounted for all of cirrhosis of the liver cirrhosis than half of the total (54.6%), AC in second place, accounting for 19.17%; AC VC98 cases accounted for 9.50%. Compared with VC, AC onset younger men more common, both were significantly different (P lt; 0.05). VC.AC and AC VC three course no statistical difference between the groups. (2) the performance of the three groups in the clinical aspects of cirrhosis only splenomegaly, spider veins and hepatic face significant difference in the incidence (P lt; 0.05). AC group with telangiectasia and spider performance is more evident, VC group, the incidence of splenomegaly than AC arm high, dull more common. The difference was statistically significant (P lt; 0.05). 3 Whether or liver cirrhosis patients with alcoholic cirrhosis complications were mainly gastrointestinal bleeding above. In liver cirrhosis and alcoholic mixed with viral cirrhosis group, according to their level of incidence of complications were the top three upper gastrointestinal bleeding, primary liver cancer and hepatic encephalopathy. Alcoholic cirrhosis incidence of hepatic encephalopathy compared with primary liver cancer is high, so the most common complications were upper gastrointestinal bleeding, hepatic encephalopathy and primary liver cancer. Three groups of upper gastrointestinal bleeding in patients with cirrhosis, hepatic encephalopathy, hepatorenal syndrome, no significant difference in the incidence (P gt; 0.05). In patients with liver cirrhosis and primary liver cancer incidence increased significantly with alcoholic cirrhosis (28.7% VS 16.2%), the difference was significant (P lt; 0.01), while the alcohol mixed with viral cirrhosis of the liver caused by factors group whose primary liver cancer incidence is even higher (30.6%). Alcoholic cirrhosis incidence of spontaneous bacterial peritonitis was significantly higher than that of liver cirrhosis group, the difference was significant (P lt; 0.01). 4 Whether liver cirrhosis or alcoholic cirrhosis, hepatic encephalopathy direct cause of death are the most common, followed by upper gastrointestinal bleeding and primary liver cancer. Mixed alcoholic cirrhosis and viral direct cause of primary liver cancer mainly places, followed by hepatic encephalopathy, upper gastrointestinal bleeding and hepatorenal syndrome. Conclusions 1. Either liver cirrhosis or alcoholic cirrhosis is the most common complication of upper gastrointestinal bleeding, the main cause of death is hepatic encephalopathy. For mixed alcohol and hepatitis viruses caused by factors cirrhosis, primary liver cancer is the most common cause of death. 2 alcoholic cirrhosis compared with spontaneous bacterial peritonitis incidence of liver cirrhosis is high. 3 main difference between the three groups is reflected in cirrhosis complications, so the prevention and treatment of complications should be noted that different areas of focus, reduce mortality.

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