The Clinical Characteristics of Premature Newborns Treated by Dexameth and Diagnosded as NRDS
|School||Chongqing Medical University|
|Keywords||Dexamethasone Preterm children Neonatal respiratory distress syndrome|
Objective: To investigate prenatal dexamethasone (dexamethasone, Dex) respiratory distress syndrome in premature children (neonatal respiratory distress syndrome, NRDS) in children with clinical characteristics and Dex prevention NRDS possible influencing factors. Methods: Children's Hospital of Chongqing Medical University from January 2003 to September 2007 hospitalized and diagnosed with premature children NRDS clinical data of 279 cases of children . Divided into antenatal Dex group ( treatment group ) and not applied Dex group ( untreated group ) , each group was divided into lt; 34 week group and ≥ 34 weeks group . Treatment group and the untreated comparison group of clinical data , Apgar score, chest X-ray grading, ventilator average number of days , etc., and the use of methods of analysis Dex . Results: 1 clinical data comparing the two groups , treatment group and the untreated group multiple pregnancy rate was 40.0 %, 19.6% ; bile stasis mother during pregnancy rates were 9.3% , 1.5%, the incidence of diabetes was 5.3 %, 2.0 % , the incidence of PIH were 13.3 %, 5.9% , two groups were statistically significant (P lt; 0.05). 2 , gestational age lt; 34周NRDS had Apgar scores of treatment group and the untreated group were 1 min: 7.78 ± 2.17,6.41 ± 2.16; 5 min: 8.59 ± 1.69,7.15 ± 2.17, the difference was statistically significant (P lt; 0.05). 3 , gestational age lt; 34周NRDS children , chest X-ray in treatment group Ⅰ , Ⅱ grade , accounting for 87.7% , without treatment group Ⅲ grade , Ⅳ grade 29.8 %, respectively, there was significant difference ( P lt; 0.05). 4, lt; 34周cure children with ventilator average number of days compared to treatment group was 3.35 ± 1.80 d, untreated group : 4.55 ± 2.57 d, the difference was statistically significant (P lt; 0.05). 5 , the first drug treatment group at delivery time, mainly in lt; 24 h and 48 h-7 d. Because of the limitations of history taking , for Dex dose , route of administration and other records are incomplete , from the available information, most hospitals using conventional dose of 10 mg, intramuscular and intravenous route of administration to give priority , especially in muscle Note as much. Conclusion : 1, Dex NRDS preventing preterm children may be affected by the disease during pregnancy , multiple pregnancy, medication and other factors, it may be speculated that genetic defects. 2 , although prenatal Dex can not completely avoid the occurrence of NRDS was able to reduce its symptoms. 3, in the prevention of further regulate prenatal Dex NRDS , while taking into account the possible side effects of Dex , you should explore other more methods .