Research on the Correlativity between the Common Chinese Medicine Syndromes of CHF and UA、LVMI
|School||Heilongjiang University of Traditional Chinese Medicine|
|Keywords||Chronic Heart Failure Chinese medicine syndromes Uric Acid Left Ventricular Mass Index|
Objective:To study the relationship between the chinese medicine syndromes of chronic heart failure(CHF)and NYHA heart function classification, uric acid (UA),left ventricular mass index (LVMI),exploring the relationship between the level of blood serum uric acid and left ventricular remodeling, research the difference of syndrome and type in such patients,and which provide the dialectical way and the theoretical basis of combined medicine treatment.Methods:We selected 85 cases,including 39 males and 46 females,and NYHAⅡ27,Ⅲ34,Ⅳ24.We divided them into four chinese medicine syndrome groups which include deficiency of Qi and Yin syndrome,qi asthenia causing blood stasis syndrome,heart-kidney yang deficiency syndrome,edema syndrome due to yang deficiency.30 healthy people were taken as a normal control group,including 13 males and 17 females.We measured their height,weight and calculated BSA by formulas.We detected their UA.All patients were observed by Color Doppler ultrasonography.We measured left ventricular end-diastolic diameter(LVDd),interventricular septum thickness (IVST),left ventricular posterior wall thickness(LVPWT),and calculated left ventricular mass(LVM),left ventricuIar massindex(LVMI).Results:1.The deficiency of Qi and Yin syndrome and qi asthenia causing blood stasis syndrome mainly in heart function classificationⅡ～Ⅲ; heart-kidney yang deficiency syndrome and edema syndrome due to yang deficiency mainly in heart function classificationⅢ～Ⅳ.2.The UA and the LVMI of different NYHA heart function classifications in CHF group are higher than the control group (p<0.01),the heightening level of UA and LVMI all wereⅡ<Ⅲ<Ⅳ(P<0.01),and the LVMI is positively correlated with UA in CHF group(r=0.640).3.The UA in CHF group is higher than the control group (p<0.01),the heightening level of UA was deficiency of Qi and Yin syndrome<qi asthenia causing blood stasis syndrome< heart-kidney yang deficiency syndrome< edema syndrome due to yang deficiency (P<0.05 or P<0.01)4.The LVMI in CHF group is higher than the control group (p<0.01), the heightening level of LVMI was deficiency of Qi and Yin syndrome< qi asthenia causing blood stasis syndrome< heart-kidney yang deficiency syndrome< edema syndrome due to yang deficiency(P<0.05 or P<0.01).Conclusions:1.The common chinese medicine syndromes of CHF has a excellent correlation with NYHA heart function classification,the study suggest that the patients who with symptom of yang deficiency were worse than those with symptom of qi deficiency.2.The UA has the excellent correlation with the LVMI can indicate that the increscent UA will be a factor which may predict left ventricular remodeling.3. The difference of UA that we can take it as one of the reference indexes of chinese medicine dialectical typing in CHF.4.The difference of LVMI that we can take it as one of the physical diagnostic indexes of chinese medicine dialectical typing in CHF.