Studies on the Synthesis and Fungicidal Activity of Novel Strobin Fungicide
|School||Hunan Normal University|
|Keywords||Organic Synthesis Antiseptic Pyraclostrobin N-methoxy carbamate Biological activity|
Strobin fungicides natural β-methoxy methacrylate derivatives based on the successful development of efficient, broad-spectrum, low toxicity and residue, unique environmental safety, mechanism of action, has become the sterilization The agent created a hot research. Come out from the first Strobin varieties in 1996, and now has nine commercial varieties, this type this year the fungicide will account for 20% of the market share of the fungicide, has become the first major fungicides varieties. This article describes the process of research and development and the latest research progress Strobin fungicides, as well as derivatives of N-alkoxy carbamate poisoning group study conducted a comprehensive summary of the literature. Fungicide pyraclostrobin (pyraclostrobin) Synthesis, Mechanism, and biological activity of new Strobin class research, a detailed discussion of the synthesis route, the experimental methods and the optimum conditions, with a total yield of 46.2%. And on this basis, the use of synthetic pyraclostrobin cytotoxic groups, hinder the cytochrome bc 1 electron transfer between a starting from the mechanism unique strobin fungicides - the use of molecular design theory, \The group-N-substituted phenyl carbamate derivatives, the synthesis of the compound structure is as follows: N-methoxy-yl-N-2-[1 - substituted phenyl - 2 - methyl thioglycolate imine oxygen methyl] benzene ylcarbamate In this paper, the theory of thermodynamics and kinetics of the process and mechanism of the reaction carried out a more detailed analysis and research. Lists all the intermediates and the physical properties of pyraclostrobin and the synthesis of new compounds by IR test means 1 sup> H NMR, MS and elemental analysis were used to characterize and discussed its spectral characteristics. Pyraclostrobin and new compounds were bactericidal activity test results of biological activity: pyraclostrobin antibacterial activity of rice blast fungus (Pyricularia oryzae), rice sheath blight fungus (Rhizoctonia solani ), Botrytis cinerea (Botrytis cinema) and wheat powdery mildew fungus (Blumeria griminis), the antibacterial activity of antibacterial activity reached 100%. Part of the new compounds in the 50 mg / L showed a good antibacterial activity, which compounds 5e suppression rice blast fungus (Pyricularia oryzae), rice sheath blight fungus (Rhizoctonia solani) and wheat powdery mildew (Blumeria griminis) bactericidal activity reached 100%, also more than 90% of the antibacterial activity of the gray mold fungus (Botrytis cinerea).