The Effect of Toxicial Element Lead, Cadmium and Nutritional Elements Calcium, Iron, Zinc, Selenium, Copper on the Growth and Development of PreSchool Children
|School||Peking Union Medical College , China|
|Course||Epidemiology and Biostatistics,|
|Keywords||Hair lead Hair cadmium Hair calcium Hair iron Hair zinc Hair Copper Hair selenium IQ Follow-up|
This study is a follow-up of the project on the basis of the pregnant women, fetal health effects in the interaction of IAEA funded toxic elements and nutrients in the original data based on the to increase preschool physical growth and mental development of the follow-up survey data. Detected by the acquisition of preschoolers hair element content, element content in the umbilical cord blood test results combined with pre-school children at birth, comprehensive evaluation of heavy metal pollution, nutrient deficiency, especially the interaction between them preschoolers physical growth and mental development. Access to preschool children through questionnaires and physical examination, family situation, growth and development and IQ situation. Acquisition preschoolers hair, using inductively coupled plasma mass spectrometry (ICP-MS) and flame atomic absorption spectrophotometry, detection of lead, cadmium, calcium, iron, zinc, selenium and copper content. The element detection quality control measures, including the use of standard reference materials and in duplicate parallel samples. Using Microsoft Excel 2007 software entry data using SAS 9.1 software for statistical analysis. Residents of children's hair trace elements of scientific research will release 13 elements normal reference range of standard groups, respectively, t test or analysis of variance, analysis of covariance and multivariate linear regression analysis, comparing preschool children hair lead, cadmium preschoolers growth and development, such as calcium, iron, zinc, selenium, copper between the different levels of group differences. Selected for preschoolers hair lead, cadmium, calcium, iron, zinc, selenium and copper level fluctuations in the 6.76-71.08μg / g, 0.06-.37 μg / g ,229.2-2077 7.7 μg / g ,133.1-495 .5 μg / g, respectively, 80.34-407.9μg / g ,0.09-1 .45 μg / g, and 8.30-37.44μg / g. The preschoolers height fluctuations in the 92.3-115.1cm, weight fluctuations in the 12.4-21.5kg, IQ fluctuation 73-155. All study subjects Spearman correlation analysis showed that preschoolers hair lead height and IQ was negatively correlated, hair cadmium and height and the IQ was negatively correlated with the high incidence of calcium group the hair calcium height and weight were positively correlated, hair iron, height and IQ positively correlated, high hair zinc group of hair zinc height and IQ was positively correlated with the high incidence of the selenium group selenium height was positively correlated with the high incidence of copper hair copper and height and weight group were positively correlated. Multiple linear analysis shows, hair lead and cadmium hair on the limit when the hair lead and hair cadmium than the reference value, the main factors to affect of preschoolers height and IQ, and also found that cord blood calcium and preschoolers Height, weight IQ is related. To be other studies to further explore the biological mechanisms of growth and development of preschool children about the toxic elements such as lead, cadmium and nutritional elements such as calcium, iron, zinc, copper and selenium.