Dissertation > Industrial Technology > Radio electronics, telecommunications technology > Microelectronics, integrated circuit (IC) > General issues > Application

Integrated capillary electrophoresis chip and detector development and research samples electrically operated

Author LiWei
Tutor ZhuMinHui;HanZuoHong
School Institute of Electronics , Chinese Academy of Sciences
Course Signal and Information Processing
Keywords Lab-on-chip Integrated Capillary Electrophoresis Chip
Type Master's thesis
Year 2000
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MEMS technology combined with the use of molecular biology techniques made ??of a certain molecular biological analysis and detection capabilities microdevices current development of the most popular kind of biological chips. It can be used to complete the separation of biological samples , preparation, biochemical reactions and product testing and a series of processes can be divided into type integrated capillary electrophoresis chip and probe array type chip. Integrated capillary electrophoresis chip ( also known as Lab-on-a-chip chips ) is conventional capillary electrophoresis technology to the square centimeter on the order of the size of the chip , the sample injection , reaction, separation , detection, integrated with the process of multifunctional fast, efficient , low-power type laboratory techniques . It has a separate analysis of miniaturization , integration, integration and automation advantages. The development of modern analytical chemistry frontier . As a Lab-On-A-Chip electrophoresis chip key features required in a few centimeters of the chip to achieve a longitudinal cross-section width not exceeding 100 micrometers cavity , this 2 × 3 cm in size in the glass , using MEMS technology engraved pitting the cross-section of about 100 × 30 micron channel , and using thermal bonding method developed cross and snake -type electrophoresis chip. Detectors are an important part of capillary electrophoresis , its sensitivity , directly affect the accuracy of the chip performance of the play . This paper uses a photomultiplier tube and a phototransistor as a photoelectric conversion part , to achieve a detector software and hardware designs. Phototransistor as potential integrated devices , the paper discusses the performance of its detection . As a Lab-On-A-Chip sample manipulation and the theoretical basis of electrophoretic separation electrodynamics effect, this paper conducted a preliminary electrical dynamics experiments carried out on the amino acid 2,4 - dinitro- fluorobenzene (DNFB) derivatized , with its derivative products to achieve a sample of electrically operated , and theoretical and electrophoretic separation factors were studied.

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