Yanbian region of hepatitis G virus infection status
|Keywords||hepatitis G virus different population infection rate|
In order to investigate the status of hepatitis G virus (HGV) pure infection and super-infection with hepatitis B virus (HBV), hepatitis C virus (HCV) in different populations in Yanbian area, the serum-markers of HGV infection were tested by enzyme linked immunosorbent assay (ELISA) from august, 1998 to October, 1999 and the biochemical index of liver function was detected in 494 cases of various liver diseases, including 278 patients with viral hepatitis diagnosed and treated in the Affiliated Hospital of Yanbian University College of Medicine, 123 cases of blood donors at the Red Cross Blood Center and 93 cases of healthy persons.The results were showed as follows: (1) Among 494 cases, the general infection rate of HGV was 6.48% (32/494), in which 8.96% (24/268) in male and 3.54% (8/226) in female that there had significant difference (x2=5.935, p=0.015); there were 8.45%(25/296) of Korean-Chinese and 3.45%(7/198) of Han nationality and there had significant difference (x2=4.722,p=0.030). The infection rate of HGV was 0% (0/5) under 20 years old, 8.89% (28/315) in the age of 20-49 and 2.40% (4/167) in the age of over 50 and there had significant difference among the groups of different age. (2) The infection status of HGV in different population were showed as follows: 2.15% (2/93) in general population, 7.31 % (9/123) in blood donors, 6.18% (3/44) in hepatocellular carcinoma, 11.36% (5/44) in cirrhosis of liver, 0% (0/5) in acute hepatitis A, 7.14% (2/28) in acute hepatitis B, 5.36% (3/56) in chronic hepatitis B, 13.33% (4/30) in chronic fulminant hepatitis B, 7.14% (3/42) in chronic hepatitis C and 3.85% (1/26) in HBsAg carriers. (3) Super-infection in HGV with other hepatitis viruses was as follows: out of 32cases of anti-HGV positive individuals, 11 cases with pure infection of HGV, the cases of super-infection with HGV and HBV, HGV and HCV, HGV, HBV and HCV, HGV and HCV were 13, 3, 5 and 0, respectively. (4) Effects of infection of HGV on liver function: liver function of patients with pure infection of HGV was normal and there was no significant difference between thatof infection of HBV and HBV + HGV . There was significant difference in the results of D-bil tests between the groups of super-infection of HBV + HCV and HBV + HCV + HGV, between the groups of that with HBV and HBV + HCV + HGV (t,=5.159, p!=0.029, t2=64.360, p2=0.000). (5) Effects of blood donor factor on HGV infection: infection rate of HGV in the people donated over and below 5years was 26.09% and 3.00%, respectively and there had significant difference between two groups (X2=14.697, p=0.000); infection rate of HGV in groups of donated 1-10 times ,11-20 times and over 21 times was 3.15%, 13.33% and 33.33%, respectively and was increased as the donating times go on (trend X2=14.752, p=0.000).The results indicate that: (1) HGV infection is prevalent to certain degree among population in Yanbian area (2) there is difference on HGV infection in nationalities. (3) HGV may be singly infected and be also infected with HBV and HCV, and the super-infection with HBV may aggravate the liver damage. (4) the patients with cirrhosis of the liver, hepatitis B and C washigh-risk population of infecting HGV. (5) the infection rate of HGV is high in blood donators and is increased as the donating times and years go on.