Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Traditional Chinese medicine chemical

Chemical constituents of Paeonia

Author ZhangXiaoYan
Tutor LiXi
School Shenyang Pharmaceutical University
Course Medicinal Chemistry
Keywords Paeonia lacflora Pall chemical constituents albiflorin R1 acetylpaeoniflorin benzoylpaeoniflorin
CLC R284
Type Master's thesis
Year 2001
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Fifteen compounds were separated from the root of Paeonia lact~flora Pall (Baishao and Chishao in Chinese) by using open-column, preparative TLC and HPLC methods et al.On the basis of physico-chemical properties and spectroscopic analysis, thirteen compounds were identified as: albiflorin R1(1) , acetyl paeoniflorin (2), oxypaeoniflorin (6), benzoylpaeoniflorin (4), galloylpaeoniflorin (5), albiflorin (7), paeoniflorin (3), 1,2,3,4, 6-pentagalloylglucose (8), galloyl acetate(12), benzoic acid (10), gallic acid (11), daucosterol (9) and P -sitosterol (13). Among them, albiflorin R1(1) and acetyl paeoniflorin (2) were novel compounds.In the molecular structure of the novel compound albiflorin R1, P -Dglucose connected with the aglycone at Glc-2 OH, while the hemiacetal hydroxyl was free. This kind of glycoside have not been discovered in the nature.Some different of components between Baishao( ~ ~) and CMshao(~~) have been observed.It was the first time that the proton signals of paeoniflorin and albiflorin were assigned completely by means of 2D-NMR and a review on the monoterpene and its glycosides obtained from Paeonia was given on the basis2of our work and references.

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