Dissertation
Dissertation > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors

The Corelation Between Smad4 and Intrahepatic Cholangiocarcinoma Progression

Author ZuoXueQiang
Tutor ChenXiaoPing
School Huazhong University of Science and Technology
Course Liver surgery
Keywords Intrahepatic cholangiocarcinoma Clinical Pathology Smad4
CLC R735.7
Type Master's thesis
Year 2010
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Objective To analyze the characteristics of the intrahepatic bile duct cell carcinoma and preliminary clinical basis for an in-depth study of intrahepatic cholangiocarcinoma . Methods A retrospective analysis of Tongji Medical College of Huazhong University of Science and Technology , Tongji Hospital from April 1985 to December 2008 , 97 cases of intrahepatic bile duct cell carcinoma clinical and pathologic data . Results (1) 43.98% ( 42 / 97 ) patients with hepatitis B surface antigen positive , the positive rate of the male group (51.61%) was significantly higher than the female group ( 28.57% ) , the difference was significant ( P lt; 0.05 ) . 2 the ICC transfer rate of the left hepatic lobe 67.27% ( 37 / 55 ) , significantly higher than the the right lobe ICC transfer rate of 40.48% ( 17 / 42 ) , the difference was significant ( P lt; 0.05 ) ; 3 pathological examination prompt - poorly differentiated tumor metastasis rate was 66.67% ( 34 / 51 ) , 43.48% ( 20 / 46 ) , higher than the well-differentiated tumors , the difference was significant ( P lt; 0.05 ) . All patients within one year recurrence rate of 27.85% ( 22 / 79 ) , the recurrence group intraoperative blood transfusion rate was 63.64% ( 14 / 22 ) was significantly higher than those without recurrence of 31.58% ( 18 / 57) , the difference between the two was significant ( P lt; 0.05 ) . Conclusion 1 . Intrahepatic bile duct cell carcinoma with chronic hepatitis B or serological HBV - positive men significantly higher than that of female . The the ICC transfer and tumor location and degree of differentiation . Transfusion is one of the risk factors for tumor recurrence . The purpose of a preliminary study of tumor suppressor gene Smad4 and intrahepatic cholangiocarcinoma (intrahepatic cholangiocarcinoma ICC) . The method using immunohistochemistry SABC method Smad4 expression in 49 cases of ICC organization , and analyze its relationship with the ICC clinical stage, pathological grade . Results Smad4 -positive ICC expression mainly located in the cytoplasm of cholangiocarcinoma cell nucleus also express ICC of Smad4 expression in the absence rate was 44.90% ( 22 / 49 ) , and with tumor stage , degree of differentiation and metastasis related ( P lt ; 0.05). Abnormal expression of Smad4 Conclusion ICC organization prompt TGF-β/Smad4 signaling pathway may play an important role in the occurrence and development process of the ICC ; closely related to the the of Smad4 expression ICC , degree of differentiation , pTNM , intrahepatic metastasis and lymph node metastasis .

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