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Dissertation > Medicine, health > Chinese Medicine > Of Pharmacy > Pharmacology

A Clinical and Experimental Study on Migubao Capsule Therapy for Primary Osteoporosis

Author WeiBing
Tutor ShenLin
School Huazhong University of Science and Technology
Course Traditional Chinese Medicine
Keywords primary osteoporosis Migubao capsule clinical observation Migubao capsule osteoporosis Pharmacodynamics
CLC R285
Type Master's thesis
Year 2010
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OBJECTIVE: To evaluate the 3-year curative effect and safety of migubao capsule in treating osteoporosis' dissertation">primary osteoporosis (Kidney—yang deficiency syndrome).Methods: Forty-eight patients with primary osteoporosis were randomly divided into Migubao group and Calcuim D group. After 3 years of administration duration, clinical curative effect was concluded and safety was evaluated.Results: Compared to control group, pain score was statistically decreased, and bone density of L2 to L4 , femur neck, trochanter major, and Ward triangle was significantly increased in Migubao group after treatment(P<0.05).Meanwhile, symptomatic scores of traditional Chinese medicine was decreased (P<0.05), such as Lumbar and knee aching, chill of limbs, pollakisuria at night, etc. No new fracture occurred during treatment. Blood, Urine, Stool routine test, hepatic function, renal function and serum electrolytes detection results fluctuated within a common range. No adverse events occurred in treatment group.Conclusion: Migubao capsule has good curative effect in treating primary osteoporosis of Kidney—yang deficiency syndrome without obvious adverse effect. So Migubao capsule is worth being popularized and applied in clinical. Objective: To study the antiosteoporosis effect s of Migubao capsule.Methods: A model of postmenopausal osteoporosis was founded in ovariectomized rats to observe the effect of Migubao capsule on bone mass, bone density and the level of serum BGP and the ratio of BYD/Cr in urine and other bone metabolism index.Results: Compared to control group,Migubao capsule can increase bone mass and density, significantly raise the level of serum BGP and decrease the ratio of BYD/Cr in urine in OP rats(P<0.05).Conclusion: Migubao capsule has a good effect on osteoporosis, which provides strong experimental evidence for clinical use.

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