Dissertation
Dissertation > Medicine, health > Oncology > Eye tumor

The Clinical Application of Proton Magnetic Resonance Spectroscopy in Orbital Tumors

Author LiYi
Tutor WeiRuiLi
School Second Military Medical University
Course Ophthalmology
Keywords Proton magnetic resonance spectroscopy Orbital tumors Benign tumor Malignancy Diagnosis Differential Diagnosis Acetic acid Lactic acid Nuclear Magnetic Resonance Spectroscopy High - resolution magic angle spinning probe
CLC R739.7
Type Master's thesis
Year 2004
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Purpose 1 investigate proton magnetic resonance spectroscopy (proton magnetic resonance spectroscopy, 1 HMRS) orbital tumors. Determination of orbital tumors in vitro specimens acetic acid, lactic acid content. Explore orbital tumors in vitro specimens of acetic acid, lactic acid and proton magnetic resonance spectroscopy measurements consistent with the acetic acid, lactic acid content in the body of orbital tumors. 4 study of orbital tumors from specimens proton nuclear magnetic resonance spectroscopy (9.395T) characteristics; explore orbital tumors from the specimens of proton nuclear magnetic resonance spectroscopy (9.395T) orbital tumors in the body proton magnetic resonance spectroscopy ( 1 HMRS) feature is consistent. The method 1 All cases underwent MRI, pathologically confirmed 1 HMRS check with 1.5T, fixed-point-resolved spectroscopy sequence (PRESS sequence) of orbital tumors and normal brain tissue in the ipsilateral frontal position acquisition, measured N-acetyl aspartate (NAA), choline (Cho), creatine (Cr), acetic acid (Ace) and lactate (Lac) wave. Get two pairs of surgical tumor specimens (including two cases of cavernous hemangioma, one cases of inflammatory pseudotumor, fibroma, venous hemangioma, eosinophilic granuloma cases) each divided into two a lactate kit orbital tumor specimens Determination of lactic acid content; a kit acetate acid content of orbital tumor specimens. 3 lactic acid, acetic acid detection kit as measured Lac / Ace value 1 HMRS the measured the Lac / Ace value for comparison. Get surgery 18 tumor samples (including five cases of cavernous hemangioma, malignant lymphoma, two cases of meningioma cases, etc.) 400MHz superconducting magnetic resonance instrument BRUKER trace high-resolution magic angle spinning (HR / MAS) 1 HNMR spectrum of test probe of orbital tumors. The area under the curve of an orbital tumor metabolites 1 HMRS performance significantly different, especially benign and malignant tumors in the acetic acid (Ace) and lactate (Lac) difference is significant (p <0.05). Lactic acid, acetic acid detection kit measured the Lac / Ace value of 3.79 ± 0.48; 1 HMRS measured the Lac / Ace value of 3.48 ± 2.10. The measured results statistically uplink t test, respectively, without significant difference (t = 0.414 0.05 / 2,10 = 2.262, P> 0.05), not statistically significant, describes two The method measured results consistent. 3 HR / MAS probe for orbital tumors can get the high resolution 1 H spectrum, can be detected in many biochemical metabolic compounds, N-acetyl aspartic acid (NAA), bile base compounds (Cho), creatine (Cr), lactate (Lac), acetate (Ace). 4 HR / MAS probe measured wave peak ratio (Cr / Lac, Cho / Cr, Lac / Ace) in and 1 the HMRS by measurement results showed no significant difference (P> 0.05). Conclusion 1 1 HMRS provide a quantitative analysis method for diagnostic imaging and clinical diagnosis of orbital tumors. The 2 orbital tumor specimens from the body of lactic acid, acetic acid test results with proton magnetic resonance spectroscopy analysis of orbital tumors in the body is the same. 3 orbital tumors in vitro specimens HR / MAS spectral characteristics with orbital tumors in the body 1 HMRS characteristics are consistent. The 4 Tips 1 HMRS check can be used in the diagnosis and differential diagnosis of benign and malignant tumor of the orbit.

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