Melatonin on acrylamide induced nerve cell protective effects of oxidative damage
|School||Huazhong University of Science and Technology|
|Keywords||Melatonin Oxidative damage Protection Nerve cells Physiological barrier ACR Cell oxidation Toxicity studies Neurotoxicity Gravis Antioxidant Ataxia Radical scavenger BBB Acrylamide Numbness Occupational Exposure Lipophilic Mechanism French fries|
Acrylamide (ACR) is a widely used chemical raw material , can be used in wastewater treatment , cosmetic manufacturing system , as well as in the laboratory synthetic dyes macromolecular electrophoretic separation . In addition to occupational exposure , ACR also cigarettes and high-temperature processing of potato and cereal foods exist, such as French fries, cookies and breads. ACR in humans and experimental animals have proven its neurotoxicity , chronic, low-dose exposure may produce occupational groups such as ataxia, muscle weakness, and numbness in hands and feet . Experimental animals exposed to every day with the crowd ACR will produce a similar progressive neurological symptoms such as ataxia and skeletal muscle weakness. Currently ACR neurotoxicity exact mechanism has not been conclusive, some studies show that oxidative damage is the result of nerve damage may be one of the mechanisms , and vitamin C and vitamin E can reduce the toxicity caused by ACR . Study found that melatonin can protect ischemia-reperfusion , inflammation, ionizing radiation and hypoxia and other pathological changes . Outside this , melatonin is an effective free radical scavenger , and has a broad-spectrum antioxidant effects. Melatonin because of its excellent lipophilic and hydrophilic , you can easily pass the in vivo physiological barriers , such as the blood-brain barrier and so on. Therefore , any part of the body melatonin may play a role in their potential antioxidant . This test result in ACR oxidative damage in PC12 cells , based on the ACR research MT induced oxidative injury in rats , as well as the MT to explore possible mechanisms for the prevention of acrylamide poisoning provide a scientific basis .