Dissertation > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug > Heterocyclic compounds drugs > Five section heterocyclic

Improvement on Albendazol Manufacturing Process

Author WangChunHua
Tutor HuXiaoPing
School Zhejiang University
Course Chemical Engineering
Keywords Albendazole Synthesis Extracted with toluene Acetone into a salt thereof Hydrochloric acid methanol solution bleaching refining Aqueous hydrochloric acid bleaching refining
CLC TQ463.53
Type Master's thesis
Year 2005
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Albendazole is a broad-spectrum , high efficiency , low toxicity anthelmintics . Its traditional synthesis and purification process has been improved to produce high quality in line with the requirements of albendazole , Smith Kline . Carbendazim as the main raw material with chlorosulfonic acid in the synthesis process , the chloro- sulfonation reaction , plus iron reduction , with sodium sulfide , the bromopropane ether , to increase the toluene extracts deodorant , Built Albendazole azole crude color is off-white powder , no odor , the purity of more than 98.0% . Study albendazole acetone hydrochloric acid to a salt-forming process , so that the separation of impurities , and also investigated albendazole significantly improved stability in acetone and hydrochloric acid , the impurity F , salified time , by controlling the acetone , the validity of preventing impurities F increases. Research albendazole hydrochloric acid methanol solution bleaching refining process , can effectively prevent the hydrolysis of albendazole , but the products contain high levels of ammonium chloride and methanol , albendazole low levels , and give up this refining process . Research albendazole aqueous hydrochloric acid bleaching refining process , also inspected the albendazole stability in aqueous hydrochloric acid impurity A significantly increased , indicating that hydrolysis , filtration time by controlling the decolorization drying can be washed with hot water and ethanol effectively prevent hydrolysis products contain the lower ammonium chloride and methanol , albendazole content of up to more than 99.0% . This refining process is produced using . The alignment process is simple , easy to get raw materials , 56% yield , product quality has reached the international advanced level , suitable for industrial production .

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