Dissertation
Dissertation > Medicine, health > Oncology > Genitourinary tumors > Breast tumor

RNA silencing hyaluronidase HYAL1 gene on human breast cancer cells malignant potential the impact of

Author TanJinXiang
Tutor RenGuoSheng
School Chongqing Medical University
Course Department of General Surgery
Keywords Angiogenesis Invasive potential Cell Cycle Human breast cancer cells Small interfering RNA RNA interference Hyaluronidase gene Reverse transcription polymerase chain reaction Gene expression levels
CLC R737.9
Type Master's thesis
Year 2005
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Objective: To investigate SiRNA-HYAL1 hyaluronidase human breast cancer cells HYAL1 gene expression . Methods: RT-PCR. Results : SiRNA-HYAL1 act on different levels of expression of hyaluronidase human breast cancer cell line MDA-MB-231, MDA-MB-453S, ZR-75-30 and ZR-75 significantly inhibited after hyaluronidase HYAL1 mRNA expression levels (P lt; 0.05). Conclusion : SiRNA-HYAL1 effect on human breast cancer cells can specifically inhibit the expression of an mRNA HYAL1 .

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