Dissertation > Medicine, health > Surgery > Orthopaedic Surgery ( movement system diseases,orthopedic surgery ) > Orthopedic surgery and surgery > Bone surgery

Prevention of Epidural Fibrosis and Adhesions with Oxiplex/SP Gel and Radiation after Laminectomy in Rats

Author LiuJiangFeng
Tutor WangShuMao
School Hebei Medical University
Course Surgery
Keywords Laminectomy Epidural fibrosis The oxiplex / SP gel Sodium hyaluronate Radiotherapy
CLC R687.3
Type Master's thesis
Year 2005
Downloads 15
Quotes 0
Download Dissertation

Objective: To observe the rabbit lumbar laminectomy epidural scar adhesions morphological changes , explore Oxiplex / SP gel , local low-dose preoperative radiotherapy effect and mechanism of prevention of epidural fibrosis , and the gel and a recognized effective anti-blocking substance - sodium hyaluronate compare understand its effectiveness . Materials and Methods: 28 healthy adult New Zealand white rabbits , male and female , regardless of the average weight of 2.5kg, were randomly divided into A, B two groups of 14 animals . Group A non - adjacent segments L1 , L3 , L5 laminectomy experimental animal models , before surgery closed in the lamina defect epidural randomly into Oxiplex / SP Gel , Sodium Hyaluronate, another parts as blank control . 14 rabbits of Group B in the 24 hours prior to surgery L5 epidural space and lamina area with gamma -ray irradiation dose of cGy area of ??3 × 3 cm size , the same total laminectomy , L3 as control . Surgical laminectomy size of 0.5 × 1.0cm , removal of the epidural fat , completely exposed dura mater , the exact hemostasis , flushing and closing the incision . Surgery closed Captivity . Batch simulation 2, 4, and 8 weeks after the original surgical method , the naked eye rabbits epidural scar formation after femoral artery quickly bled animals were killed , to take surgery spine specimens were examined by light microscopy and electron microscopy the morphological observations , the result of observing the principle of self-control for statistical analysis . Results: The the Rydell - Balazs adhesion toughness ratings marked vertebral rating pathologic observations , the control group has a large number of dense epidural scar formation , and the formation of adhesions between the dura mater . Only a small amount of sodium hyaluronate group

Related Dissertations
More Dissertations