Dissertation > Medicine, health > Chinese Medicine > TCM Internal Medicine > Modern medicine, internal diseases

A Prospective Study of TGP in the Treatment of Ankylosing Spondylitis

Author DongHongYu
Tutor BiLiZuo
School Jilin University
Course Internal Medicine
Keywords Total glucosides of peony Ankylosing spondylitis Efficacy Forward-looking
CLC R259
Type Master's thesis
Year 2005
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Objective : To observe the TGP (TGP) for ankylosing spondylitis (AS) effect, to evaluate the safety , tolerability and the abnormal immune function , and discuss the best treatment. Methods: divided into two groups . Treatment group 40 cases , conventional treatment TGP, daily TGP1.8g, three times daily , orally 24wk. The control group 40 cases , conventional treatment SASP, gradually increase the amount of oral 24wk. Observed clinical parameters and laboratory indicators for efficacy evaluation , evaluation of safety and tolerability . Results: 1, treatment of the control group after 6-12wk clinical indicators of improvement rate than the treatment group ; 2 24wk after treatment , both groups showed no clinical indicators of improvement rate differences ; 3 , 0,24 wk after treatment were detected experiments Room SASP group showed elevated transaminase , reduced white blood cells , platelets reduce , TGP group does not appear above changes ; 4 , two groups before and after treatment compared with the control group, the total effective rate was slightly higher than the treatment group , but no significant between the two groups differences ; 5 , compared with the control group treated adverse reactions adverse reactions occurred more than the control group, adverse reactions are gastrointestinal symptoms, changes in liver function , reduced white blood cells and platelets , treatment, adverse reactions to gastrointestinal symptoms . Conclusion: TGP has anti-inflammatory , analgesic, immunomodulatory effects, can improve the clinical symptoms of AS patients , remission of disease , most patients can also improve sleep, appetite and physical and other general conditions , you can also correct anemia , side effects small and light, and can reduce the side effects of MTX , long-term application of tolerability and safety than SASP was excellent , the patient was well tolerated , safe , TGP is a safe and effective anti -rheumatic drugs , can DMARD combined therapy of AS.

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