Dissertation > Medicine, health > Internal Medicine > Blood and lymphatic system diseases > Blood diseases > Hemorrhagic disease > Purpura

The Disscuss of the TNF-α、IL-8、IFN-γ Effect of ITP Complicated by HP Infection

Author YuPeng
Tutor QiaoZhenHua
School Shanxi Medical
Course Department of Hematology
Keywords Idiopathic thrombocytopenic purpura(ITP) Helicobacter pylori TNF IFN-γ IL-8 platelet count
CLC R554.6
Type Master's thesis
Year 2005
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Objective: To compare the cytokines TNF-α 、 IL-8、 IFN- γ before and after the eradication of HP infection in patients with ITP.and to explore the relation of the three cytokine and the platelet count.Methods: We selected 40 patients of the ITP complicated HP infection,half of which(A1 group)are given HP eradication treatment,while the others(A2 group) aren’t given.30 ITP patients of the HP negative are taken as B group.30 healthy peoples are taken as C group. The 14C urea breath test(14C-UBT) was utilized to diagnose of HP infection.Before and after the treatment,TNF-α、 IL-8 、 IFN-γ are measured by the ELISA method.The effect of the three cytokines to platelets is observed.Result :(1)Campared the TNF-α、 IFN-γ and IL-8 of groups,A1 group showed TNF- α、 IFN-γ significantly higher than the B and C group(p<0.05) .The thirty and the sixty day ,A1 and A2 groups also showed very significantly change(p<0.05) of the TNF-α、 IFN- γ while the IL-8 of the patients don‘t have much change (p>0.05).(2) After the HP treatment ,the platelet count of ITP patients complicated HP infection rose significantly (p<0.05).(3)The platelet count and TNF-α、 IFN- γ of the A1 group showed obvious negative correlation.Conclusion: Part of the ITP patients are related to the TNF-α、 IFN-γ ,which are released after HP infection. So the HP treatment is an important addition to the ITP treatment.

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