The Disscuss of the TNF-α、IL-8、IFN-γ Effect of ITP Complicated by HP Infection
|Course||Department of Hematology|
|Keywords||Idiopathic thrombocytopenic purpura(ITP) Helicobacter pylori TNF IFN-γ IL-8 platelet count|
Objective: To compare the cytokines TNF-α 、 IL-8、 IFN- γ before and after the eradication of HP infection in patients with ITP.and to explore the relation of the three cytokine and the platelet count.Methods: We selected 40 patients of the ITP complicated HP infection,half of which（A1 group）are given HP eradication treatment,while the others（A2 group） aren’t given.30 ITP patients of the HP negative are taken as B group.30 healthy peoples are taken as C group. The 14C urea breath test(14C-UBT) was utilized to diagnose of HP infection.Before and after the treatment,TNF-α、 IL-8 、 IFN-γ are measured by the ELISA method.The effect of the three cytokines to platelets is observed.Result :（1）Campared the TNF-α、 IFN-γ and IL-8 of groups,A1 group showed TNF- α、 IFN-γ significantly higher than the B and C group（p<0.05） .The thirty and the sixty day ,A1 and A2 groups also showed very significantly change（p<0.05） of the TNF-α、 IFN- γ while the IL-8 of the patients don‘t have much change （p>0.05）.（2） After the HP treatment ,the platelet count of ITP patients complicated HP infection rose significantly （p<0.05）.（3）The platelet count and TNF-α、 IFN- γ of the A1 group showed obvious negative correlation.Conclusion: Part of the ITP patients are related to the TNF-α、 IFN-γ ,which are released after HP infection. So the HP treatment is an important addition to the ITP treatment.