Dissertation > Industrial Technology > Chemical Industry > Basic Organic Chemistry Industry > The production of aromatic compounds > Aromatic nitrogen compounds

Synthesis of 3-amino-4-methoxy-acetanilide

Author ShengJianYu
Tutor PengXinHua
School Nanjing University of Technology and Engineering
Course Applied Chemistry
Keywords 3-amino-4-methoxy-acetanilide 4-nitrochlorobenzene dyestuff pharmaceutical synthesis
Type Master's thesis
Year 2005
Downloads 181
Quotes 5
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3-Amino-4-methoxy-acetanilide is an important intermediate used for synthesizing synthesizing some dyestuffs and pharmaceuticals. A total synthesis of 3-amino-4-methoxy-acetanilide starting from 4-nitrochlorobenzene, followed by methoxylation, reduction, acylation and nitration reactions etc., was studied. The total yield was improved to 80.0 % in a purity of 99.2 %. Some rational technological parameters, related reaction mechanisms and reaction conditions were discussed. The structures and compositions of these compounds were accomplished by spectral analysis and chromatographic analysis.

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