Quqianling Attenuates Learning and Memory Deficits Induced by Lead Exposure in the Rat
|School||Hunan Normal University|
|Keywords||Removing lead Spirit Lead Exposure Spatial learning Reference memory Working memory|
The lead contamination is widespread global environmental problems , and chronic low-level exposure to lead can damage a variety of human neurobehavioral and cognitive functions , animal research and clinical practice proved early chronic low level lead exposure can cause adult continuing cognitive impairment . Has been antagonistic on the lead chelating and lead toxicity is very concerned about , but there are many inadequacies excretion of drugs in clinical application . Therefore , the research and development of security , convenience, efficiency, toxicity and removing lead early essential drugs . In this study, the main observe the effect of removing lead spiritual whether low-level lead exposure induced learning and memory impairment antagonism hope to provide a new , safe treatment for removing lead . In this study, by 0.05% lead acetate contamination SD rats drinking water for 28 days, using the Morris water maze learning and memory behavior model to observe the impact of chronic low-level lead exposure on learning and memory of adult rats . At the same time , the administration side of the lead edge dyed observe three different doses of removing lead Ling extract powder (3.47g/kg/d, 6.93g/kg/d, 13.86g/kg/d) of lead exposure in animal learning antagonism and memory impairment . The results found that chronic low-level exposure to lead can cause damage to the adult rat spatial reference memory and spatial working memory , but does not affect the animals use cognitive map strategy to find the hidden platform , had no effect on spatial learning . Chinese medicine is obvious antagonism toxic effects of lead on Lead spirits , can significantly improve the performance in the Morris water maze of lead- exposed animals , which in the dose of removing lead spiritual role best , and the dose is too high and too low are lower less than the best effect . Blood lead levels also prove that low-level lead exposure to blood lead values ??, and allows the body to form a stable drive the lead spiritual group of animal blood lead concentration was significantly lower than that of lead exposure group , prompted flooding lead Spirit Lead role . The results showed that : 1 , chronic low-level exposure to lead can cause the rats memory impairment , Spirit of removing lead antagonism memory impairment caused by chronic low-level lead exposure .