Design, Synthesis and Antitumor Activity of thalidomide derivatives
|School||Nanjing Normal University|
|Course||Microbial and Biochemical Pharmacy|
|Keywords||thalidomide synthetic and design Du145 anti-tumor activity|
The rescent mechanism and pharmacological studies on the actions of Thalidom-de were reviewed in this dissertation.Thalidomide was selscted as a lead-compound for structural modification according to characteristics of it’s chemical structure and pharmaceutical activities. With 4-Pipradrol and halogeno-arene as starting materials,16 target compounds was obtained by Ullmann reaction, Mitsunobu reaction and so on,which have not been reported in the literatures.Thestructures of those compounds were confirmed by 1H-NMR,MS and IR.The pilot study of the anti-tumor property was carried out by Du145 cell line,with Doxorubicin as positive control.The results of the experiment on Du145 showed that most of target compounds have no activities.In order to observe the anti-tumor effects of target compounds significantly, other tumor cell line should be tried.