Dissertation > Medicine, health > Pharmacy > Pharmacology

Effects of Cefodizime on the T-lymphocyte Subsets of Peripheral Blood in Mice

Author WangPeng
Tutor ZuoQuanCheng;YuZuJiang
School Zhengzhou University
Course Immunopharmacology
Keywords Cefodizime Immunological liver injury associated with sepsis T cell subsets
Type Master's thesis
Year 2005
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Effective antibiotic therapy , the organism 's defense mechanisms must participate. The single role of antimicrobial drugs is not the role of drugs on the bacteria , but the antimicrobial agents , the interaction between the body and pathogens a complex process . The Cefodizime (Cefodizime, CDZM) as the new third-generation cephalosporins , β - lactamase enzyme stability is strong , with broad-spectrum antimicrobial activity . Existing research found cefodizime more significant antimicrobial activity in vivo , especially for the treatment of immunodeficient animals experimentally infected model made ??clear effect , suggesting a synergistic effect on the host's defense function while its antimicrobial , which is other antibiotics are not available . Clinically , it can not only better control the infection, and can fully mobilize the body's immune regulatory function , serious infections , especially in immune deficiency syndrome (immunodeficiency disease, IDD) infected patients , more appropriate for infectious opened up new avenues to the treatment of the disease , has a very positive clinical value in use . Viral hepatitis, liver damage is humoral and cellular immunity together the results , rather than direct damage of the hepatitis virus , the same time, in the event of severe hepatitis ( severe of viral hepatitis , SH) , the immune system declines , the intestinal mucosa through increased permeability and other factors lead to bacterial translocation , infection , sepsis is an important cause of death for patients with fulminant hepatitis , while Cefodizime severe hepatitis and liver injury in patients with sepsis animal model of immune regulation at home and abroad have not been reported . Peripheral blood T cell subsets and the ratio reflects an important indicator of the state of immune regulation . In this paper, by research Cefodizime to normal mice and autoimmune liver injury associated with sepsis mice regulation of peripheral T cell subsets to further to examine Cefodizime immunomodulatory effects , clinical diagnosis and immunotherapy for viral hepatitis provide a theoretical basis .

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