Dissertation > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetic coma and other complications

Effects of Methylcobalamin on Diabetic Peripheral Neuropathy: a Systematic Review of Randomized Evidence

Author JiaHaiYan
Tutor TianHaoMing
School Sichuan University
Course Internal Medicine
Keywords Methyl vitamin B12 Diabetic Peripheral Neuropathy System Evaluation Randomized controlled trials Quasi-randomized controlled trials Meta- analysis
CLC R587.2
Type Master's thesis
Year 2004
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The background diabetic peripheral neuropathy is chronic complications of diabetes is the most common serious impact on a patient 's quality of life . There is no effective treatment methods , and strict control of blood glucose is the basic measures of prevention and treatment of diabetic neuropathy . However , in patients with a certain illness duration of strict control of blood sugar does not make fully improved neurological function , and may cause severe hypoglycemia . Therefore, on the basis of strict glycemic control integrated application of other treatments . Small randomized controlled trials , there are many methyl vitamin B 12 treatment of diabetic peripheral neuropathy methyl vitamin B 12 improve diabetic peripheral neuropathy signs and symptoms , increased nerve conduction velocity , and effectively improve the patient 's quality of life . Objective To understand whether there is sufficient evidence methyl vitamin B 12 efficacy and safety of treatment of diabetic peripheral neuropathy , should the clinical as conventional drugs for the treatment of diabetic peripheral neuropathy . The method in accordance with the method of systematic review of the international Cochrane Collaboration , retrieve worldwide methyl vitamin B 12 treatment of diabetic peripheral neuropathy randomized or quasi-randomized controlled trials , including : the Cochrane Library clinically controlled trials library Medline, Embase database , Chinese Biomedical literature Database , Chinese Science and Technology journal full-text database and retrieved article references . Two investigators independently trials met the inclusion criteria , quality assessment and data extraction . Using the following indicators of methyl vitamin B 12 efficacy of the treatment of diabetic peripheral neuropathy and the

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