Dissertation
Dissertation > Industrial Technology > Chemical Industry > Pharmaceutical chemical industry > Production of organic compounds in drug > Aliphatic compounds, drugs

The Research of Capsule Formulation、Preparation Technology as Well as Quality of Meformin Hygdrochloride Enteric-coated a Tiny Capsules

Author ZhongYuMei
Tutor ZuoLiRong;FuBoTao
School Jilin University
Course Biological Engineering
Keywords Enteric-coated pellets of metformin hydrochloride capsules Centrifugal granulation Acrylic L30D-55
CLC TQ463.2
Type Master's thesis
Year 2006
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Metformin has become the preferred biguanide hypoglycemic diabetes . Based mainly in the intestinal absorption of metformin hydrochloride and irritation of the stomach larger features, we have developed a unique \capsules , one can avoid the release of the drug in the stomach , thereby reducing side effects, on the other hand , the drug release in the intestine , is conducive to the absorption of drugs . Granulation mechanism by centrifugal coating prepared pellets , to determine the 60-40 mesh microcrystalline cellulose (MCC) Blank pill core of the nucleus , with 5% hydroxypropyl methyl cellulose (HPMC) (5cp) aqueous solution of an adhesive agent, prepared by powder layered pellets , then Germany acrylic resin ( Eudragit , Eudraqit) L30D-55 aqueous dispersion of the coating material after preparation of enteric-coated pellets filled capsules , enteric-coated pellets made capsules , and using UV spectrophotometry was established in metformin hydrochloride pellets and release test methods . By quality testing, prepared according to the above enteric-coated pellets of metformin hydrochloride high drug loading , the content of 72.5% , an acid for 2 hours, 11.4% release , buffer salts release in 45 minutes , 86.7 , 98.1 cumulative release % . Because pharmaceutical companies years of work experience , I metformin hydrochloride enteric-coated pellets capsule formulation design , manufacturing process and quality of research produced a strong interest. To make the drug in practical use can play a greater value , Jilin University, studying for my Master of Engineering during the teacher 's guidance, in recent years, the domestic application of enteric-coated pellets of metformin hydrochloride capsules conducted in-depth treatment of diabetes research . Metformin hydrochloride is a new release carrier of enteric-coated pellets , except with the general characteristics of enteric preparations such as avoiding gastric irritation , the enteric-coated pellets can significantly improve the uniformity of drug release , reduce individual differences, which for maintaining stable blood glucose is important. Expected , metformin hydrochloride enteric-coated pellets

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